王程远，中国科学院上海药物研究所研究员，博士生导师、研究组长。入选国家海外高层次人才计划、上海市海外高层次人才计划、上海市浦江人才计划。兼任上海市微生物学会基础微生物专业委员会委员。长期从事致力于研究耐药菌重要抗生素开发靶点机制研究和利用药用植物天然代谢产物筛选抗致病微生物药物的工作，尤其关注于致病微生物转录调控过程重要靶点分子机制。近年来以通讯（含共同）及第一作者在Nature，Science，PNAS，Nature Communications，Science Advance等杂志发表多篇论文。作为Nature Communications，Nature Computational Science，Science Bullet，Science China Life Science，Structure等期刊审稿人，并担任ABBS，hLife杂志青年编委。
围绕病原微生物RNA聚合酶和核糖体为中心，探索转录与翻译的调控机制；并基于这些重要分子机器为靶点，结合植物、微生物天然代谢产物开发新型抗生素先导化合物。本课题组结合生物化学、结构生物学以及微生物学的技术手段聚焦一下研究方向：
（1）微生物转录翻译偶联过程的分子机制及功能研究
（2）微生物因子依赖型转录终止过程的分子机制及功能研究
（3）微生物特殊翻译起始过程的分子机制及功能研究
（4）植物、微生物抗菌天然代谢产物的鉴定、分离及合成通路解析
2025年
1.Guan, H., Wu, H., Gan, M., Zhang, J., Wang, J., Liu, S., Chen, S., Jiao, Y., Li, F., Huang, S., Lin, S., Chen, H., Feng, Y., Cheng, C., Song, H., Wang, C., Zheng, L., Fu, J., Ouyang, S., 2025. Contact-dependent antagonism is mediated by a T7SSb toxin effector-immunity protein pair via ADP-ribosylation. Sci Bull 2025
2.Li, R.; Zhang, Molodtsov, V.*; Wang, C.*. Structural insights from the bacterial world: Coordination of transcription-translation coupling and transcription termination in Archaea. hLife 2025.
3.Zhang, Y., Li, R., Zheng, D., Zhao, J., Qing, K., He, R., Ma, Z., Chen, J., Xue, N., Tian, X., Wang, E., Xu, J., Li, Y., Tan, B., Zhou, Z., Wang, C., Dong, J., 2025. Phosphoglycerate dehydrogenase is required for kernel development and defines a predominant serine synthesis pathway in maize. Plant Cell 2025
4.Shen, J.; Zhang, Y.; Tang, W.; Yang, M.; Cheng, T.; Chen, Y.; Yu, S.; Guo, Q.; Cao, L.; Wang, X.; Xiao, H.; Wang, L.; Wang, C.; Liu, C. Y.*; Meng, G.*, Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth. Nat Immunol 2025.
5.Chen, B.; Mao, J.; Xu, K.; Liu, L.; Lin, W.; Guo, Y. W.*; Wu, R.*; Wang, C.*; Xu, B.*, Mining coral-derived terpene synthases and mechanistic studies of the coral biflorane synthase. Sci Adv 2025, 11, (9), eadv0805.
2024年
6. Zhang, J.#; Zhang, S.#; Zhou, W.#; Zhang, X.#; Li, G.; Li, R.; Lin, X.; Chen, Z.; Liu, F.; Shen, P.; Zhou, X.; Gao, Y.*; Chen, Z.*; Chao, Y.*; Wang, C.*, A widely conserved protein Rof inhibits transcription termination factor Rho and promotes Salmonella virulence program. Nat Commun 2024, 15, (1), 3187.
7. You, L.#; Wang, C.#; Molodtsov, V.#; Kuznedelov, K.; Miao, X.; Wenck, B. R.; Ulisse, P.; Sanders, T. J.; Marshall, C. J.; Firlar, E.; Kaelber, J. T.; Santangelo, T. J.; Ebright, R. H.*, Structural basis of archaeal FttA-dependent transcription termination. Nature 2024, 635, (8037), 229-236.
8. Molodtsov, V.#; Wang, C.#; Zhang, J.; Kaelber, J. T.; Blaha, G.; Ebright, R. H.*, Structural basis of RfaH-mediated transcription-translation coupling. Nat Struct Mol Biol 2024, 31, (12).
9. Li, J. F.#; Chen, B.#; Fu, Z. Y.#; Mao, J. J.#; Liu, L. J.; Chen, X. C.; Zheng, M. Y.; Wang, C. Y.; Wang, C.*; Guo, Y. *; Xu, B.*, Discovery of a terpene synthase synthesizing a nearly non-flexible eunicellane reveals the basis of flexibility. Nat Commun 2024, 15, (1).
10. Li, J.; Cui, H.; Yao, Y.; Niu, J.; Zhang, J.; Zheng, X.; Cui, M.; Liu, J.; Cheng, T.; Gao, Y.; Guo, Q.; Yu, S.; Wang, L.; Huang, Z.; Huang, J.; Zhang, K.; Wang, C.*; Meng, G.*, Anti-influenza activity of CPAVM1 protease secreted by Bacillus subtilis LjM2. Antiviral Res 2024, 228, 105919.
2023年
11. Molodtsov, V.#; Wang, C.#*; Firlar, E.; Kaelber, J. T.; Ebright, R. H.*, Structural basis of Rho-dependent transcription termination. Nature 2023, 614, (7947), 367-374.
12. Li, J. C.; Yang, M. X.; Li, W. J.; Lu, C. J.; Feng, D. Y.; Shang, Z.; Wang, C.*; Lin, W.*, Structural and functional characterization of a mycobacterial methylenetetrahydrofolate reductase utilizing NADH as the exclusive cofactor. Biochem J 2023, 480, (14), 1129-1146.
2022年
13. Zhang, J.; Ma, Y.; Chen, Q.; Yang, M.; Feng, D.; Zhou, F.; Wang, G.*; Wang, C.*, Functional Prediction of trans-Prenyltransferases Reveals the Distribution of GFPPSs in Species beyond the Brassicaceae Clade. Int J Mol Sci 2022, 23, (16).
14. Wang, C.; Wang, Y.; Chen, J.; Liu, L.; Yang, M.; Li, Z.; Wang, C.; Pichersky, E.; Xu, H.*, Synthesis of 4-methylvaleric acid, a precursor of pogostone, involves a 2-isobutylmalate synthase related to 2-isopropylmalate synthase of leucine biosynthesis. New Phytol 2022, 235, (3), 1129-1145.
2021年
15. Wang, C.#; Li, J. X.; Ma, M. L.; Lin, Z. Z.; Hu, W. L.; Lin, W.*; Zhang, P.*, Structural and Biochemical Insights Into Two BAHD Acyltransferases (AtSHT and AtSDT) Involved in Phenolamide Biosynthesis. Front Plant Sci 2021, 11.
2021年之前
16. Wang, C.#; Molodtsov, V.#; Firlar, E.; Kaelber, J. T.; Blaha, G.; Su, M.; Ebright, R. H.*, Structural basis of transcription-translation coupling. Science 2020, 369, (6509), 1359-1365.
17. Wang, H.; Wang, C.; Fan, W.; Yang, J.; Appelhagen, I.; Wu, Y.; Zhang, P.*, A novel glycosyltransferase catalyses the transfer of glucose to glucosylated anthocyanins in purple sweet potato. J Exp Bot 2018, 69, (22), 5444-5459.
18. Zhou, F.#; Wang, C.#; Gutensohn, M.; Jiang, L.; Zhang, P.; Zhang, D.; Dudareva, N.; Lu, S.*, A recruiting protein of geranylgeranyl diphosphate synthase controls metabolic flux toward chlorophyll biosynthesis in rice. PNAS 2017, 114, (26), 6866-6871.
19. Zhang, J.; Huang, W.; Yuan, C.; Lu, Y.; Yang, B.; Wang, C.; Zhang, P.; Dobens, L.; Zou, Z.; Wang, C.; Ling, E., Prophenoloxidase-Mediated Ex Vivo Immunity to Delay Fungal Infection after Insect Ecdysis. Front Immunol 2017, 8, 1445.
20. Li, J.#; Wang, C.#; Yang, G.; Sun, Z.; Guo, H.; Shao, K.; Gu, Y.; Jiang, W.; Zhang, P., Molecular mechanism of environmental d-xylose perception by a XylFII-LytS complex in bacteria. PNAS 2017, 114, (31), 8235-8240.
21. Wang, C.#; Chen, Q.#; Fan, D.; Li, J.; Wang, G.; Zhang, P., Structural Analyses of Short-Chain Prenyltransferases Identify an Evolutionarily Conserved GFPPS Clade in Brassicaceae Plants. Mol Plant 2016, 9, (2), 195-204.
22. Qi, X.; Lin, W.; Ma, M.; Wang, C.; He, Y.; He, N.; Gao, J.; Zhou, H.; Xiao, Y.; Wang, Y.; Zhang, P., Structural basis of rifampin inactivation by rifampin phosphotransferase. PNAS 2016, 113, (14), 3803-8.
23. Zhao, Q.; Wang, C. C.; Wang, C.; Guo, H.; Bao, Z. H.; Zhang, M. H.; Zhang, P., Structures of FoIT in substrate-bound and substrate-released conformations reveal a gating mechanism for ECF transporters. Nat Commun 2015, 6.
24. Yu, F.; He, F. Y.; Yao, H. Y.; Wang, C.; Wang, J. C.; Li, J. X.; Qi, X. F.; Xue, H. W.; Ding, J. P.; Zhang, P., Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex. Embo Rep 2015, 16, (7), 813-823.
25. Lin, W.; Wang, Y.; Han, X. B.; Zhang, Z. L.; Wang, C.,Wang, J.; Yang, H. Y.; Lu, Y. H.; Jiang, W. H.; Zhao, G. P.; Zhang, P., Atypical OmpR/PhoB Subfamily Response Regulator GlnR of Actinomycetes Functions as a Homodimer, Stabilized by the Unphosphorylated Conserved Asp-focused Charge Interactions. J Biol Chem 2014, 289, (22), 15413-15425.
26. Xu, K.; Zhang, M. H.; Zhao, Q.; Yu, F.; Guo, H.; Wang, C.; He, F. Y.; Ding, J. P.; Zhang, P., Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis. Nature 2013, 497, (7448), 268-+.