江维

主要研究兴趣

模式识别受体活化和调控机制研究

模式识别受体调节肠道粘膜稳态的机制研究

肠道上皮内淋巴细胞功能及发育分化研究

中国科学技术大学教授，博士生导师，免疫应答与免疫治疗全国重点实验室课题组负责人。中组部“万人计划”科技创新领军人才、科技部创新人才推进计划“中青年科技领军人才”，国家基金委优秀青年基金获得者。研究成果获国家自然科学二等奖（第二完成人，2019）、安徽省自然科学一等奖（第二完成人，2023）。

长期从事无菌性炎症中的固有免疫识别、调控及疾病干预策略研究：鉴定免疫系统识别“危险信号”或肠道共生微生物的关键受体，有助于理解病理生理条件下的免疫稳态维持和炎症发生机制，为炎症性疾病干预提供了新的候选靶点；揭示危险识别受体NLRP3及其形成的炎症小体的关键活化和调控机制，有助于理解重大疾病中无菌性炎症的发生和转归机制；基于无菌性炎症新理论和新靶点，研制一批靶向危险感应受体的抑制剂，为2型糖尿病和肿瘤等疾病免疫治疗提供了新路径。以（共）第一/通讯作者在Science（2022）、Cell（2015）、Nat Rev Immunol （2020、2024）、Nat Immunol（2014, 2019, 2024）、Nat Cell Biol（2020）、Immunity（2013、2021、2024）等发表论文30余篇。

近期学术论文

1. Yan J, Zhang C, Xu Y, Huang Z, Ye Q, Qian X, Zhu L, Huang G, Wang X, Jiang W, Zhou R. GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity. Nat Immunol.2024 Oct 2. doi: 10.1038/s41590-024-01973-z. 

2. Huang Y, Jiang W, Zhou R.  DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways.Nat Rev Immunol. 2024 Apr 29. doi: 10.1038/s41577-024-01027-3

3. Ma M, Jiang W, Zhou R. DAMPs and DAMP-sensing receptors in inflammation and diseases.Immunity. 2024 Apr 9;57(4):752-771.

4. Huang Y, Zhou R. Cytosolic transfer of circulating LPS by EVs. Nat Cell Biol. 2023 Nov 16. doi: 10.1038/s41556-023-01283-w.

5. Xu Y, Yan J, Tao Y, Qian X, Zhang C, Yin L, Gu P, Liu Y, Pan Y, Tang R, Jiang W, Zhou R. Pituitary hormone α-MSH promotes tumor-induced myelopoiesis and immunosuppression. Science. 2022 Sep 2;377(6610):1085-1091. doi: 10.1126/science.abj267

6. Wang X, Cai J, Lin B, Ma M, Tao Y, Zhou Y, Bai L, Jiang W, Zhou R. GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair. Immunity.2021 Jun 8;54(6):1123-1136.e8

7.  Huang Y, Wang H, Hao Y, Lin H, Dong M, Ye J, Song L, Wang Y, Li Q, Shan B, Jiang Y, Li H, Shao Z, Kroemer G, Zhang H, Bai L, Jin T, Wang C, Ma Y, Cai Y,Ding C, Liu S, Pan Y, Jiang W, Zhou R. Myeloid PTEN promotes chemotherapy-induced NLRP3 inflammasome activation and antitumor immunity. Nat Cell Biol. 2020 Jun;22(6):716-727.

8. Gong T, Liu L, Jiang W, Zhou R. DAMP-sensing receptors in sterile inflammation and inflammatory diseases.Nat Rev Immunol. 2020 Feb;20(2):95-112. 

9.  Gong T, Zhou R. ApoC3: an 'alarmin' triggering sterile inflammation.Nat Immunol. 2020 Jan;21(1):9-11.

10. Liu L, Gong T, Tao W, Lin B, Li C, Zheng X, Zhu S, Jiang W, Zhou R. Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling.Nat Immunol. 2019 Dec;20(12):1681-1691

11.Lang X,Tang T,Jin T,Ding C,Zhou R,Jiang W. TRIM65-Catalized ubiquitination is essential for MDA5-mediated antiviral innate Immunity. J Exp Med.2017;214(2):459-473.

12.Gong T,Wang X,Yang Y,Yan Y,Yu C,Zhou R,Jiang W. Plant Lectins Activate the NLRP3 Inflammasome To Promote Inflammatory Disorders.J Immunol.2017;198(5):2082-2092.

13.Tang T, Lang X, Xu C, Wang X, Gong T, Yang Y, Cui J, Bai L, Wang J, Jiang W*, Zhou R*. CLICs- dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Nat Commun. 2017;8(1):202.（*co-corresponding author）

14.Yan Y*, Jiang W*, Liu L, Wang X, Ding C, Tian Z, Zhou R. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell. 2015;160(1-2):62-73.（*co-first author）

15.Wang X*, Jiang W*, Yan Y, Gong T, Han J, Tian Z, Zhou R. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat Immunol. 2014;15(12):1126-33.（*co-first author）

16.Jiang W, Wang X, Zeng B, Liu L, Tardivel A, Wei H, Han J, MacDonald HR, Tschopp J, Tian Z, Zhou R. Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes.J Exp Med. 2013;21;210(11):2465-76.

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