苏枭，中国科学院特聘研究岗位 (二级研究员)，博士生导师，免疫应答与免疫治疗全国重点实验室课题组负责人。2004年获复旦大学和美国UCSF联合培养博士学位；2004～2007美国UCSF博士后；2007～2012美国UIC助理研究教授和UCSF副研究员；2012年担任呼吸道感染免疫课题组组长。提出肺副交感神经炎症反射弧学说，开拓了迷走神经调控肺部感染免疫的领域，形成了神经调控肺感染免疫的专业特色。在Lancet、Nature Med、Cell Stem Cell、Adv Sci、Mol Ther、Cell Discov、Am J Respir Crit Care Med 等发表文章100多篇； 主持国家自然科学基金重点、重大集成重点、重大项目子课题、重点专项等项目、 上海市基础重点项目、承担国家重点研发计划和中国科学院先导B项目等。 获得美国Parker B. Francis肺生物医学奖，美国NIH Ruth L. Kirschstein奖、省/市级科技进步奖，华夏医学科技二等奖等。牛津大学出版社QJM（Oxford）、Mol Med（Springer Nature）等杂志副主编；国家和香港等重要基金、人才项目评审专家；参与制订国家自然科学基金呼吸领域十三、十四五战略规划等。
1. 神经调控肺损伤、修复的环路和机制
2.神经调控哮喘的环路和机制
3. 神经调控病毒复制和致病机制
1.Chen J, Xie S, Lin Z, Zhao C, Tao R, Ma Y, Chen X, Wu R, Sui P, Wang S, Ji H, Song H, Zhang X, Sun Y, Song Y, Su X *. Neural circuits between nodose ganglion and pulmonary neuroendocrine cells regulate lung inflammatory responses. Adv Sci. 2025, doi: https://10.1002/adv.202507512
2.Feng X, Xue Y, Bao R, Chen S, Yang H, Xie F, Sun J, Su X*. Disruption of the Vagal TRPA1-Pulmonary Neuroendocrine Cell Axis Reduces Asthma Severity. Allergy. 2025 Jun;80(6):1715-1736. doi: 10.1111/all.16599
3.Zhao C, Chen J, Liu Z, Liang H, Chen X, Cheng L, Xie S, Lin Z, Wu R, Zhao Q, Xue Y, Lai X, Jin X, Xu J and Su X*. Activation of nicotinic acetylcholine receptor α7 subunit limits ZIKV infection via promoting autophagy and ferroptosis. Mol Ther 2024 May 30:S1525-0016(24)00339-3. doi: 10.1016/j.ymthe.2024.05.037.
4.Zhang G, Lian Y, Li Q, Zhou S, Zhang L, Chen L, Tang J, Liu H, Li N, Pan Q, Gu Y, Lin N, Wang H, Wang X, Guo J, Zhang W, Jin Z, Xu B, Su X*, Lin M*, Han Q*, Qin J*. Vagal pathway activation links chronic stress to decline in intestinal stem cell function. Cell Stem Cell. 2025 Mar 20:S1934-5909(25)00084-0. doi: 10.1016/j.stem.2025.02.016.
5.Chen X, Zhang C, Wei T, Chen J, Pan T, Li M, Wang L, Song J, Chen C, Zhang Y, Song Y, Su X*. Activation of α7nAChR in AT2 promotes alveolar regeneration through WNT7B signaling in acute lung injury. JCI Insight 2023 Aug 8;8(15):e162547. doi: 10.1172/jci.insight.162547.
6.Chen J, Lai X, Song Y and Su X*. Neuro-immune Recognition and Regulation in the Respiratory System. European Respiratory Review 2024; 0: 240008； DOI: 10.1183/16000617.0008-2024.
7.Du J, Liu Y, Lan G, Zhou Y, Ni Y, Liao K, Zheng F, Cheng Q, Shi G, Su X*. PTRF-IL33-ZBP1 signaling mediating macrophage necroptosis contributes to HDM-induced airway inflammation. Cell Death Dis. 2023 Jul 15;14(7):432. doi: 10.1038/s41419-023-05971-1.
8.Zhao C, Pan M, Chen C, Li L, Zhang Y, Liu W, Matthay MA, Wang H, Jin X, Xu J and Su X*. Vagal-α7 nicotinic acetylcholine receptor signaling exacerbates influenza severity by promoting lung epithelial cell infection. J Med Virol. 2024 Jul;96(7):e29768. doi: 10.1002/jmv.29768.
9.Liu L, Zhang DY, Xu JY, Dai HP, Tang N, Su X, Cao B. SARS-CoV-2 viral sepsis: from bedside to bench. Lancet. 2020 May 9;395(10235):1517-1520. doi: 10.1016/S0140-6736(20)30920-X.
10.Huang X, Hao S, Liu J, Huang Y, Liu M, Xiao C, Wang Y, Pei S, Yu T, Xu J, Wang H, Dai D, Su X*, Xiao Y*. The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity. Cell Mol Immunol. 2021 Apr;18(4):969-978. doi: 10.1038/s41423-021-00660-5.
11.Zhao C, Yang X, Su EM, Huang Y, Li L, Matthay MA*, Su X* Signals of vagal circuits engaging with AKT1 in α7 nAChR+CD11b+ cells lessen E. coli and LPS-induced acute inflammatory injury. Cell Discov. 2017 Apr 11;3:17009. doi: 10.1038/celldisc.2017.9. eCollection 2017.
12.Zhao CQ, Chen J, Cheng LP, Xu KF, Yang YY*, and Su X*. Deficiency of HIF-1α enhances influenza A virus replication by promoting autophagy in alveolar type II epithelial cells. Emerg Microbes Infect. 2020 Dec;9(1):691-706. doi: 10.1080/22221751.2020.1742585.
13.Zhang C, Zhao CQ, Chen XY, Tao RJ, Meng GX, Liu X, Shao CZ*, Su X*. Induction of ASC pyroptosis requires gasdermin or caspase-1/11-dependent mediators and IFN-β from pyroptotic macrophages to Stem Cells. Cell Death Dis. 2020 Jun 18;11(6):470. doi: 10.1038/s41419-020-2664-0.
14.Zhang H, Xue K, Li W, Yang X, Gou Y, Su X, Qian F, Sun L. Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity. Nat Commun. 2024 Jan 4;15(1):252. doi: 10.1038/s41467-023-44168-0.
15.Li Y, Lu Y, Lin SH, Li N, Han Y, Huang Q, Zhao Y, Xie F, Guo Y, Deng B, Tsun A, Du J, Li D, Sun J, Shi G, Zheng F, Su X, Duan S, Zheng SG, Wang G, Tong X, Li B. Insulin signaling establishes a developmental trajectory of adipose regulatory T cells. Nat Immunol. 2021 Aug 24. doi: 10.1038/s41590-021-01010-3.
16.Tang J, Sun H, Chang H, Yuan L, Chen Y, Zhang X, Tao Y, Yang L, Shao Z, Guo X, Zhou H, Sheng H, Zou Q, Su X, Qiu J, Qin J, Qiu J. Brg1-imprinted chromatin status controls effector and memory group 2 innate lymphoid cell metabolism to exacerbate allergic lung inflammation. J Allergy Clin Immunol. 2025 Sep 17:S0091-6749(25)00948-0. doi: 10.1016/j.jaci.2025.08.029.
17.Gao ZW, Li L, Huang YY, Zhao CQ, Xue SJ, Chen J, Yang ZZ, Xu JF*, Su X*. Vagal-α7nAChR signaling is required for lung anti-inflammatory responses and arginase 1 expression during an influenza infection. Acta Pharmacol Sin. 2021 Jan 7. doi: 10.1038/s41401-020-00579-z.
18.Su X*, Robriquet L, Folkesson HG, Matthay MA. Protective Effect of Endogenous Beta Adrenergic Tone on Lung Fluid Balance in Acute Bacterial Pneumonia in Mice. Am J Physiol Lung Cell Mol Physiol. 2006, 290: L769-776. DOI: 10.1152/ajplung.00334.2005.
19.Su X*, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA. Activation of the α7 Nicotinic Acetylcholine Receptor Reduces Acid-induced Acute Lung Injury in Mice and Rats. Am J Respir Cell Mol Biol. 2007; 37:186-192. DOI: 10.1165/rcmb.2006-0240OC.
20.Su X*, Johansen M, Looney MR, Brown EJ, Matthay MA. CD47 Deficiency Protects Mice from Lipopolysaccharide-Induced Acute Lung Injury and Escherichia coli Pneumonia. J Immunol. 2008; 180:6947-53. DOI: 10.4049/jimmunol.180.10.6947.
21.Su X*. Leading neutrophils to the alveoli: who is the guider? Am J Respir Crit Care Med. 2012; 186:472-3. DOI: 10.1164/rccm.201207-1235ED.
22.Matthay MA*, Su X*. Pulmonary barriers to pneumonia and sepsis.Nature Med. 2007, 13:780-781. DOI: 10.1038/nm0707-780.
23.Su X*, Matthay MA, Malik AB. Requisite Role of the cholinergic α7 nAChR Pathway in Suppressing Gram-negative Sepsis-induced Acute Lung Inflammatory Injury. J Immunol. 2010; 184(1): 401-410. DOI: 10.4049/jimmunol.0901808.
24.Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA. PAR2 activation induces acute lung inflammation by neuropeptide dependent mechanisms. J Immunol. 2005, 175: 2598-2605. DOI: 10.4049/jimmunol.175.4.2598.
25.Su X, Wang L, Song Y, Bai C. Inhibition of inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute lung injury induced by lipopolysaccharide. Intensive Care Med. 2004; 30:133-40. DOI: 10.1007/s00134-003-2001-y.
26.Su X, Bai C, Hong Q, Zhu D, He L, Wu J, Ding F, Fang X, Matthay MA. Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury. Intensive Care Med. 2003; 29:2034-2042. DOI: 10.1007/s00134-003-2017-3.
27.苏枭. 急性肾衰竭的诊断和治疗. 崔书章主编《实用危重病医学》.天津科技出版社, 2000.
28.苏枭. 急性肺损伤的实验方法. 白春学主编《急性呼吸窘迫综合征》. 上海科技出版社, 2005.