肖晖，研究员，免疫应答与免疫治疗全国重点实验室课题组负责人。1991年于武汉大学生命科学学院获学士学位；1997年博士毕业于中国科学院上海植物生理研究所；随后在美国华盛顿大学作博后和凯斯西储大学任高级研究助理；2005年受聘于美国克里夫兰临床医学中心免疫学系，任项目科学家；2010年加入中国科学院上海巴斯德研究所，任免疫信号转导与调节研究组组长，博士生导师。美国免疫学家协会会员、中国免疫学会、细胞学会和微生物学会会员。主要研究天然免疫系统调节炎症因子和干扰素表达的信号转导机制，挖掘防治感染、炎症和肿瘤的新靶标。主持了国家自然科学基金委重点项目（三项）和中国科学院国际合作重点项目，承担了国家973计划、国家重点研发计划等项目。近年作为通讯作者（包括共同通讯作者）在Immunity、Nat Immunol、Sci Immunol、J Exp Med和J Clin Invest等重要免疫学期刊上发表研究论文30多篇，获得了教育部自然科学奖一等奖（2020）和多项专利授权。

1.阴离子通道LRRC8/VRAC转运cGAMP调节病毒感染和肿瘤免疫；

2.代谢物影响免疫力的新机制鉴定和新靶点研发；

3.免疫记忆与耗竭的关键节点及其在肿瘤治疗与疫苗研发中的应用。

1.Cao L., Wang L., Li Z., Wei X., Ding J., Zhou C., Chen X., Huang Z., Shao Z., Shen J., Lou H., Zhao K., Huang Y., Yang Y., Liu H., Sun Y., Niu J., Jiang S., Lu R., Tang L., Zhang X., Zhang H., Xiao Y., Chen J., Ma S., Gao C., Meng G., Li L., Qiu Z., Wang H., Deng L., Ye Y., Jia X., Li H.*, Xiao H*. Radiotherapy Enhances Anticancer CD8 T Cell Responses by cGAMP Transfer through LRRC8A/C Volume-Regulated Anion Channels. Science Immunology 2025 June 27. 10(108): eadn1630. *通讯作者

2.Shao Z, Wang L, Cao L, Chen T, Jia XM, Sun W*, Gao C*, Xiao H*. The protein segregase VCP/p97 promotes host antifungal defense via regulation of SYK activation. PLoS Pathog. 2024 Oct 29;20(10): e1012674. *通讯作者

3.Wang L, Cao L, Li Z, Shao Z, Chen X, Huang Z, He X, Zheng J, Liu L, Jia XM*, Xiao H*. ATP-elicited Cation Fluxes Promote Volume-regulated Anion Channel LRRC8/VRAC Transport cGAMP for Antitumor Immunity. J Immunol. 2024 Aug 1; 213(3):347-361. *通讯作者

4.Wu H, Wang L, Wang W, Shao Z, Jia XM, Xiao H*, Chen J*. The secretory Candida effector Sce1 licenses fungal virulence by masking the immunogenic β-1,3-glucan and promoting apoptosis of the host cells. mLife. 2023 Jun 26;2(2):159-177. *通讯作者

5.Chen X, Wang L, Cao L, Li T, Li Z, Sun Y, Ding J, Zhou C, Xie Y, Yue N, Nan J, Jia XM, Peng C, Li H, Yang J*, Xiao H*. Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2'3'-Cyclic GMP-AMP and Cisplatin under Steady State and Inflammation. J Immunol. 2021 May 1;206(9):2061-2074. *通讯作者

6.Zhou C, Chen X, Planells-Cases R, Chu J, Wang L, Cao L, Li Z, López-Cayuqueo KI, Xie Y, Ye S, Wang X, Ullrich F, Ma S, Fang Y, Zhang X, Qian Z, Liang X, Cai SQ, Jiang Z, Zhou D, Leng Q, Xiao TS, Lan K, Yang J, Li H, Peng C, Qiu Z*, Jentsch TJ*, Xiao H*. Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity. 2020 May 19; 52: 767-781. *通讯作者

7.Xie Y, Zhao Y, Shi L, Li W, Chen K, Li M, Chen X, Zhang H, Li T, Yu MI, Yao X, Shao D, Ke Z, Li J, Chen Y, Zhang X, Cui J, Cui S, Leng Q, Cadwell K, Li X, Wei H, Zhang H, Li H*, Xiao H*. Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer. J Clin Invest. 2020 Apr 1;130(4):2111-2128. *通讯作者

8.Shi L, Chen X, Zang A, Li T, Hu Y, Ma S, Lü M, Yin H, Wang H, Zhang X, Zhang B, Leng Q*, Yang J*, Xiao H*. TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis. PLoS Biol. 2019 Aug 21;17(8): e3000420. *通讯作者

9.Wang W, Deng Z, Wu H, Zhao Q, Li T, Zhu W, Wang X, Tang L, Wang C, Cui SZ, Xiao H*, Chen J*. A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection. Nat Commun. 2019, Mar 4;10(1):1015. *共同通讯作者

10.Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, Zhou C, Fang Y, Liu J, Yang J, Chen X, Li T, Zang A, Yin S, Li B, Plumas J, Chaperot L, Zhang X, Xu G, Jiang L, Shen N, Xiong S, Gao X, Zhang Y, Xiao H*. Epigenetic regulator CXXC5 recruit DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017, 214(5):1471-1491. *通讯作者

11.Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H*. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol. 2015,16:642-652. *通讯作者

12.He L, Zang A, Du M, Ma D, Yuan C, Zhou C, Mu J, Shi H, Li D, Huang H, Deng Q, Xiao J, Yan H, Hui L, Lan K, Xiong S, Li X, Huang Z, Xiao H*. mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines. Virologica Sinica. 2015, 30:1-16. *通讯作者

13.Xiao H#, Yin W, Khan M, Gulen MF, Zhou H, Sham HP, Jacobson K, Vallance BA and Li X. Loss of SIGIRR leads to enhanced colonic polyposis in Apcmin mice. Gastroenterology 2010, 139:574-585. #第一作者

14.Xiao H#, Gulen MF, Qin J, Yao J, Bulek K, Kish D, Altuntas CZ, Walde D, Ma C, Zhou H, Tuohy VK, Fairchild R, de la Motte C, Cua D, Vallance BA, and Li X. The Toll-Interleukin-1 receptor member SIGIRR regulates colonic epithelia homeostasis, inflammation and tumorigenesis. Immunity 2007, 26:461-75. #第一作者