冯岁寒，研究员，博士生导师，免疫应答与免疫治疗全国重点实验室课题组负责人。2014年博士毕业于欧洲分子生物学实验室（EMBL Heidelberg），随后在瑞士日内瓦大学生物化学系从事博士后研究，2020年晋升为助理研究员（Maître Assistant）。2021年加入中国科学院上海巴斯德研究所，担任研究员和课题组长；2025年加入中国科学院上海药物研究所。课题组从事脂质的功能与代谢研究，主要在以下方面开展研究：开发光控化学生物学技术、结合高分辨质谱研究脂质代谢的动态变化；利用脂质组学技术发掘脂质在病原感染与炎症中的关键作用，并揭示其调控机制；开发脂质递送系统用于核酸和药物递送。以通讯/第一作者身份在Angewandte Chemie、eLife、Chemical Science、ACS Central Science等杂志发表多篇论文。其中开发的探针分子先后被德国SiChem GmbH公司和美国Avanti Polar Lipids公司商品化。

1.发展脂质组学（lipidomics）技术用于免疫代谢研究

2.开发光控探针研究脂质从活体到亚细胞层面的代谢动态及调控机制

3.脂质用于药物递送

1.Jiménez-Rojo, N#; Feng S.#; Morstein J.#; Pritzl, S.D., Harayama, T; Asaro, A.; Vepřek, N.A.; Arp, C. J.; Reynders, M.; Novak, AJE; Kanshin E.; Ueberheide B.; Lohmüller, T; Riezman H.; Trauner D. Optical Control of Membrane Fluidity Modulates Protein Secretion. ACS Cent. Sci., online.

2.Wang, X.; Tian, S.; Feng, S.*. A photoactivatable chemical lipidomics approach for local lipid metabolic analysis. Methods, 2025, 242, 62-71.

3.Lei, Z.#, Wei, W.#, Wang, M.#, Xu, Y.#, Bai, L., Gao, Y., Jiang, C., Li, F., Tian, N., Kuang, L., Zhu, R., Pang, G., Lan, K.*, Feng, S.*, Liang, X*. PINLYP-mediated phospholipid metabolism reprogramming contributes to chronic herpesvirus infection. Plos Pathogen, 2025, 21 (5), e1013146.

4.Xiong Q.; Zhu Z.; Li T.; Li X.; Zhou Z.; Chao Y.; Yang C.; Feng S.; Qu Q.; Li D. Molecular architecture of human LYCHOS involved in lysosomal cholesterol signaling. Nat. Struct. Mol. Biol., 2025, 32, 905-913.

5.Li X; Tian S; Riezman I; Qin Y; Riezman H; Feng S.* A sensitive, expandable AQC-based LC-MS/MS method to measure amino metabolites and sphingolipids in cell and serum samples. J. Chromat. B. 2024, 1245:124256.

6.Simon C.; Asaro A.; Feng S.; Riezman H. Organelle-specific photoactivation and dual-isotope labeling strategy reveals phosphatidylethanolamine metabolic flux. Chem. Sci., 2023, 14, 1687-1695.

7.Girik, V.#, Feng, S.#*, Hariri, H., Henne, MW; Riezman, H.*, Vacuole-Specific Lipid Release for Tracking Intracellular Lipid Metabolism and Transport in Saccharomyces cerevisiae. ACS Chem Biol, 2022, 17(6), 1485-1494. (# equal contribution; * corresponding author)

8.Chang, D.; Feng, S.; Girik, V.; Riezman, H.; Winssinger, N., Luciferase Controlled Protein Interactions. J Am Chem Soc 2021, 143 (10), 3665-3670.

9.Feng, S.; Harayama, T.; Chang, D.; Hannich, J. T.; Winssinger, N.; Riezman, H., Lysosome-targeted photoactivation reveals local sphingosine metabolism signatures. Chem Sci 2019, 10 (8), 2253-2258.

10.Chang, D.; Lindberg, E.; Feng, S.; Angerani, S.; Riezman, H.; Winssinger, N., Luciferase-Induced Photouncaging: Bioluminolysis. Angew Chem Int Ed Engl 2019, 58 (45), 16033-16037.

11.Feng, S.; Harayama, T.; Montessuit, S.; David, F. P.; Winssinger, N.; Martinou, J. C.; Riezman, H., Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function. Elife 2018, 7, e34555.

12.Nadler, A.; Yushchenko, D. A.; Muller, R.; Stein, F.; Feng, S.; Mulle, C.; Carta, M.; Schultz, C., Exclusive photorelease of signalling lipids at the plasma membrane. Nat Commun 2015, 6, 10056.

13.Feng, S.; Laketa, V.; Stein, F.; Rutkowska, A.; MacNamara, A.; Depner, S.; Klingmuller, U.; Saez-Rodriguez, J.; Schultz, C., A rapidly reversible chemical dimerizer system to study lipid signaling in living cells. Angew Chem Int Ed Engl 2014, 53 (26), 6720-3.