邵孟乐，中国科学院上海药物研究所研究员、课题组长，免疫应答与免疫治疗全国重点实验室课题组负责人。2007年本科毕业于上海交通大学，2013年于中国科学院上海营养科学研究所获得博士学位。后赴美国得州大学西南医学中心开展博士后研究，2019年晋升助理讲师。2021年加入中国科学院上海巴斯德研究所，任研究员和课题组长。课题组聚焦能量代谢稳态研究，运用遗传学工具与多组学手段解析复杂代谢调控网络的生理功能及其与疾病的关系。实验室建立以来以通讯作者（含共同）在Nature Cell Biology、Nature Metabolism等期刊发表研究工作，涉及组织器官代谢可塑性、小分子代谢产物、脂肪前体细胞等研究方向。

1.Yao T, Tian X, Rao L, Ni J, Yu J, Yang H, Tang Y, Huang X, Xia X, Zhao L, Diao B, Ping Y, Wei D, Li S, Chai H, Hu Z, Ruan X, Feng S, Shao M#, Shan B#, Wu Y#. Lipid-dependent accrual of a subset of monocyte-derived macrophages is essential for tissue regeneration. Nature Metabolism. 2026;8(3):646-665 (# Co-corresponding author) (News & Views in Nature Metabolism)

2.Ping Y, Qin Z, Huang X, Sun Q, Yao T, Li S, Tian X, Xia X, Diao B, Zhao L, Zhang X, Wei D, Wang L, Shao M#, Wu Y#, Huang J#, Shan B#. Perivascular mesenchymal cells instruct ST2+ reparative macrophages to promote endovascular injury-induced neointimal hyperplasia. Nature Communications. 2026 (# Co-corresponding author)

3.Cheng L, Cheng J, Liang G, Wang X, Ge Y, Liu J, Cai L, Ying H, Wang F, Hu J, Wang Y, Scherer PE, Zhou B#, Shao M#, Zhang F#. PDGFR+ DPP4+ fibroblast-macrophage crosstalk induces orbital fibrosis in treatment-resistant thyroid eye disease via the GAS6-AXL pathway. Advanced Science. 2025; Accepted. (# Co-corresponding author)

4.Fu T, Sun W, Xue J, Zhou Z, Wang W, Guo Q, Chen X, Zhou D, Xu Z, Liu L, Xiao L, Mao Y, Yang L, Yin Y, Zhang X, Wan Q, Lu Bin, Chen Y, Zhu M, Scherer PE, Fang L, Piao H, Shao M#, Gan Z#. Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes. Nature Cell Biology. 2023;25(6):848-864 (# Co-corresponding author) (Commented by Nature Cell Biology)

5.Shan B*, Barker CS*, Shao M*, Zhang Q, Gupta RK, Wu Y. Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity. Cell Metabolism. 2022;34:783-799 (* Co-first author) 

6.Shao M, Hepler C, Zhang Q, Shan B, Vishvanath L, Henry GH, Zhao S, An YA, Wu Y, Strand DW, Gupta RK. Pathological HIF1α Signaling Drives Adipose Progenitor Dysfunction in Obesity. Cell Stem Cell. 2021;28(4):685-701 (Cover story; commented by Cell Stem Cell)

7.Shan B*, Shao M*, Zhang Q, Hepler C, Paschoal VA, Barnes SD, Vishvanath L, An YA, Malladi VS, Strand DW, Gupta OT, Oh D, Gupta RK. Perivascular Mesenchymal Cells Control Adipose Tissue Macrophage Accrual in Obesity. Nature Metabolism. 2020;2(11):1332-1349 (* Co-first author) (Highlighted by Nature Reviews Endocrinology)

8.Shao M, Ishibashi J, Kusminski CM, Wang QA, Hepler C, Vishvanath L, MacPherson KA, Spurgin SB, Sun K, Holland WL, Seale P, Gupta RK. Zfp423 maintains white adipocyte identity through suppression of the beige cell thermogenic gene program. Cell Metabolism. 2016;23:1167-1184

9.Shao M*, Zhang Q*, Truong A, Shan B, Vishvanath L, Li L, Seale P, Gupta RK. ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes. Genes & Development. 2021;35:1461-1474 (* Co-first author) (Commented by Genes & Development)

10.Shan B*, Shao M*, Zhang Q, An YA, Vishvanath L, Gupta RK. Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual. Genes & Development. 2021;35:1333-1338 (* Co-first author) (Cover story; commented by Genes & Development)

11.Z*, Shao M*, Hepler C, Zi Z, Zhao S, An YA, Zhu Y, Ghaben AL, Wang M, Li N, Onodera T, Joffin N, Crewe C, Zhu Q, Vishvanath L, Kumar A, Xing C, Wang QA, Gautron L, Deng Y, Gordillo R, Kruglikov I, Kusminski CM, Gupta RK, Scherer PE. Dermal Adipose Tissue Has High Plasticity and Undergoes Reversible Dedifferentiation in Mice. Journal of Clinical Investigation. 2019;129(12):5327-5342 (* Co-first author)

12.Shao M*, Wang QA*, Song A, Vishvanath L, Busbuso NC, Scherer PE, Gupta RK. Cellular Origins of Beige Fat Cells Revisited. Diabetes. 2019;68:1874-1885 (* Co-first author)

13.Shao M, Vishvanath L, Busbuso NC, Hepler C, Shan B, Sharma AX, Chen S, Yu X, An YA, Zhu Y, Holland WL, Gupta RK. De novo adipocyte differentiation from Pdgfrβ⁺ preadipocytes protects against pathologic visceral adipose expansion in obesity. Nature Communications. 208;9:890

14.Liu Y*, Shao M*, Wu Y, Yan C, Jiang S, Liu J, Dai J, Yang L, Li J, Jia W, Rui L, Liu Y. Role for the endoplasmic reticulum stress sensor IRE1α in liver regenerative responses. Journal of Hepatology. 2015;62:590-598 (* Co-first author)

15.Shao M*, Shan B*, Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, Jia W, Li J, Li J, Rui L, Yang L, Liu Y. Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling. Nature Communications. 2014;5:3528 (* Co-first author)

16.Mao T*, Shao M*, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Y, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W, Liu Y. PKA phosphorylation couples hepatic inositol-requiring enzyme1α to glucagon signaling in glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America. 2011;108:15852-15857 (* Co-first author)