潘磊，研究员，博士生导师，免疫应答与免疫治疗全国重点实验室课题组负责人。国家级人才，入选第六批国家高层次人才特殊支持计划，中国科学院青年创新促进会成员，优秀会员择优支持，上海市青年拔尖人才，中国科学院卓越中心骨干，入选中国细胞生物学学会青年科学家。现任中国科学院大学学位评定委员会生命科学学位评定委员会委员，中国科学院分子病毒与免疫重点实验室副主任，中国昆虫学会昆虫微生物组学专委会委员，上海市昆虫学会理事。担任免疫应答与免疫治疗全国重点实验室课题组长。2004年毕业于南开大学生命科学学院。同年免试就读于中国科学院生物物理研究所。之后入选博士联合培养计划，在美国Stowers生物医学研究所完成全部研究生学业。2010年获中国科学院细胞生物学博士学位。同年，直接竞聘为中国科学院生物物理研究所副研究员。仅四年破格晋升为正高级研究员，博士生导师。实验室长期从事病原-宿主互作的免疫遗传学开拓性研究，探索病原致病机理以及天然免疫和机体重要生理病理应答通路之间的互作机制。目前重点关注急慢性感染以及非感染性持续炎症过程中，局部紊乱如何诱发远端器官介导的系统性并发炎症，特别是肠轴器官（肠肝，肠脑，肠肌，肠肤等）间的免疫、代谢、神经交流机制。实验室分别利用果蝇和小鼠模型搭建有多种病原（真菌、细菌、RNA病毒）感染模型以及糖尿病、肥胖症、肠炎、肿瘤、神经退行性疾病等多种生理病理模型。仅第一作者和通讯作者在Nature，Cell Stem Cell, Cell Host Microbes, Nature Microbiology等高水平期刊上发表研究成果30余篇，多篇入选F1000。并作为项目负责人或骨干承担国家重点研发、973、十二五攻关、中科院先导A/B、基金委国际重大等课题10余项。同时参与上海广播电台直播，自然博物馆线上访谈等多项科普社会活动，参与主编科普和专业书籍5部。
1.病原-宿主互作的免疫遗传学研究
2.急慢性感染/非感染炎症中，局部-系统的器官间交流机制，重点关注肠轴器官对话
3.病原/宿主跨界小分子物质鉴定(DAMPs/PAMPs)
4.病原检测和抗病原物质研发
1.Jie Li*, Guangsheng Chen*, Xiangkang Zeng*, Jiaxin Lin, Xiaoqing Chen, Wenqiang Wang, Yueru Tian, Xinhua Huang, Yun Zou, Ming Guan, Zhiyi He, Hailei Wang, Changbin Chen#, Lei Pan#. Profiling the host defense responses against the emerging fungal pathogen Candida auris in a reliable Drosophila melanogaster infection model.mLife, 2025. DOI: 10.1002/mlf2.70038
2.Lei Geng, Zhen Fan, Rongbing Chen, Kyu-Chan Cho, Yining Liu, Yu Cheng, Jingfeng Yang, Ying Zhang, Xuefei Wei, Liyuan Gong, Yingyu Tang, Zhan Xu, Wuren Huang, Shahzad Toufeeq, Zongzhao Zhai, Lei Pan, Jun Zhang, Bin Li, Brenda T Beerntsen, Ji-Hoon Lee, Youli Xiao, Younghwa Na, Won-Jae Lee, Erjun Ling. The Nα-Acetyl-L-lysine/Loxl2/H2O2 promotes intestinal tumor growth in Drosophila and cell proliferation in human colorectal cancer. Cell Reports, 2025. PMID: 40811058
3.Wen Y, Liu Y, Li Q, Tan J, Fu X, Liang Y, Tuo Y, Liu L, Zhou X, LiuFu D, Fan X, Chen C, Chen Z, Wang Z, Fan S, Liu R, Pan L#, Zhang Y#, Tang WH#. Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm. Circ Res. 2024 Apr 30. doi: 10.1161/CIRCRESAHA.124.324323. Epub ahead of print. PMID: 38686580.（#Correspondence author）
4.Tian-Yi Zhang, Yao-Qi Chen, Jing-Cong Tan, Jin-An Zhou, Wan-Ning Chen, Tong Jiang, Jin-Yin Zha, Xiang-Kang Zeng, Bo-Wen Li, Lu-Qi Wei, Yun Zou, Lu-Yao Zhang, Yue-Mei Hong, Xiu-Li Wang, Run-Ze Zhu, Wan-Xing Xu, Jing Xi, Qin-Qin Wang, Lei Pan, Jian Zhang, Yang Luan, Rui-Xin Zhu, Hui Wang, Changbin Chen & Ning-Ning Liu. Global fungal-host interactome mapping identifies host targets of candidalysin. Nat Communs 15, 1757 (2024). https://doi.org/10.1038/s41467-024-46141-x
5.Yaya Zhao, Miaomiao Zhang, Huaping Li, Yiwen Yang, Xiaofu Lu, Junjing Yu, Lei Pan. Aldo-keto reductase 1B: Much learned, much more to do. hLife (2024) Doi:10.1016/j.hlife.2023.12.002
6.Lei Wang, Jiaxin Lin, Kaiyan Yang, Weina Wang, Yan Lv, Xiangkang Zeng, Yaya Zhao, Junjing Yu, Lei Pan. Perilipin 1 Deficiency Prompts Lipolysis in Lipid Droplets and Aggravates the Pathogenesis of Persistent Immune Activation in Drosophila. J Innate Immun 2023;15:697–708 DOI: 10.1159/000534099
7.Yuhui Gao, Shi Yu, Mengdan Chen, Xun Wang, Lei Pan, Bin Wei and Guangxun Meng. cFLIPS regulates alternative NLRP3 inflammasome activation in human monocytes. Cell Mol Immunol (2023). https://doi.org/10.1038/s41423-023-01077-y
8.Yuanyuan Wang, Yinhe Mao, Xiaoqing Chen, Xinhuang Huang, Zhongyi Jiang, Kaiyan Yang, Lixing Tian, Tong Jiang, Yun Zou, Xiaoyuan Ma, Chaoyue Xu, Zili Zhou, Xianwei Wu,Lei Pan, Huaping Liang, Lin Zhong, Changbin Chen (2023) Homeostatic control of an iron repressor in a GI tract resident. eLife 12:e86075
9.Miao Zhang, Yueming Ma, Xianglu Ye, Ning Zhang, Lei Pan# and Bing Wang#. TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases. Signal Transduction and Targeted Therapy, 8, 261 (2023). (#Correspondence author)
10.Xiaofen Wu，Kongyan Niu，Xiaofan Wang，Jing Zhao，Han Wang，Hui Wang，Ting Miao，Yun Yang，Huanhuan Ma，Yaoyang Zhang，Lei Pan，Rui Liu，Hua Bai，Nan Liu. microRNA-252 and FoxO repress inflammaging by a dual inhibitory mechanism on Dawdle mediated TGF-β pathway in Drosophila. GENETICS,2022, 3;220(3):iyab234
11.Lei Wang*, Jiaxin Lin*, Junjing Yu, Kaiyan Yang, Li Sun, Hong Tang, Lei Pan. Downregulation of Perilipin1 by the Immune Deficiency Pathway Leads to Lipid Droplet Reconfiguration and Adaptation to Bacterial Infection in Drosophila. Journal of Immunology, 2021, 207: 1-12.
12.Shuo Yang*, Yaya Zhao*, Junjing Yu*, Zhiqin Fan, Si-tang Gong, Hong Tang, Lei Pan. Sugar Alcohols of Polyol Pathway Serve as Alarmins to Mediate Local-Systemic Innate Immune Communication in Drosophila. Cell Host & Microbe (2019), 10.1016/j.chom.2019.07.001
13.Yang S, Zhao Y, Yu J, Fan Z, Gong S-T, Tang H, Pan L. Establishment of Viral Infection and Analysis of Host-Virus Interaction in Drosophila Melanogaster. J. Vis. Exp., doi:10.3791/58845 (2018).
14.Yang S, Yu J, Fan Z, Gong S-T, Tang H, Pan L. 2018. Bub1 facilitates virus entry through endocytosis in a model of Drosophila pathogenesis. J Virol 92:e00254-18 (2018)
15.Xiaomeng He*, Junjing Yu*, Min Wang, Yang Cheng, Yanan Han, Shuo Yang, Lei Sun, Ying Fang, Si-tang Gong, Zhong Wang, Yang-Xin Fu, Lei Pan# and Hong Tang#. Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice. Nature Microbiology, 2, 17056 (2017). (#Correspondence author)
16.Pan L*, Wang S*, Lu T, Weng C, Song X, Park J, Sun J, Yang Z, Yu J, Tang H, McKearin D, Chamovitz D, Ni J, Xie T. Protein competition switches the function of COP9 from self-renewal to differentiation. NATURE, 2014; doi:10.1038/nature13562
17.Yan D, Neumuller RA, Buckner M, Ayers K, Li H, Hu Y, Yang ZD, Pan L, Wang X, Kelley C, Vinayagam A, Binari R, Randklev S, Perkins LA, Xie T, Cooley L, and Perrimon N. A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal. Developmental Cell 2014, 28, 459–473. (Resource article)
18.Chen J*, Zhao Y*, Zhang C*, Chen H*, Feng J, Chi X, Pan Y, Du J, Guo M, Cao H, Chen H, Wang Z, Pei R, Wang Q, Pan L, Niu J, Chen X, Tang H. Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice. Cell Research, 2014;doi:10.1038
19.Yu J*, He X*, Chen Y, Hao Y, Yang S, Wang L, Pan L# and Tang H#. Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins. J BIOL CHEM 2013, 288 (1): 79-88 (#Correspondence author)
20.Zhang X, Weng C, Li Y, Wang X, Jiang C, Li X, Xu Y, Chen Q, Pan L# and Tang H#. Human Bop is a novel BH3-only member of the Bcl-2 protein family. Protein Cell 2012, 3 (10): 790–801 (Correspondence author)
21.Wang X*, Pan L*, Wang S, Zhou J, Tang H, Xie T. Histone H3K9 Trimethylase Eggless Controls Germline Stem Cell Maintenance and Differentiation. Plos Genetics 2011, 7(12): e1002426 (co-first author)
22.Yu J*, Pan L*, Qin X, Chen H, Xu Y, Chen Y, Tang H. MTMR4 attenuates TGFβ signaling by dephosphorylating R-Smads in endosomes. J Biol Chem. 2010 Mar 12;285 (11):8454-62. (Co-first Author)
23.Xie T#, Song X, Jin Z, Pan L, Weng C, Chen S, Zhang N. Interactions between Stem Cells and Their Niche in the Drosophila Ovary. Cold Spring Harb Symp Quant Biol 2008;73, 39-47. (Annual review)
24.Pan L, Chen S, Weng C, Call G, Zhu D, Tang H, Zhang N, Xie T. Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary. Cell Stem Cell. 2007;1:458-469.
25.Lei Wang*, Jiaxin Lin*, Junjing Yu, Zhiqin Fan, Hong Tang, and Lei Pan.(2020) Adaptive modification of lipid droplets mediated by Plin1 functions in infection-induced pathogenesis in Drosophila. bioRxiv DOI: 10.1101/2020.04.30.070292
专著：
Drosophila Protocol eBook（第一版）ISBN：978-1-951285-01-2
Yu, J. J., Yang, S. and Pan, L. (2019). Smurf assay to detect Drosophila intestine leakage. Bio-101 e1010267. Doi: 10.21769/BioProtoc.10101267
Zhao, Y. Y., Yu, J. J. and Pan, L. (2019). Using nano-injection to prepare models of DCV infected Drosophila. Bio-101 e1010288. Doi: 10.21769/ BioProtoc.10101288.
Wang, L. and Pan, L. (2018). Infection of adult Drosophila by septic injury. Bio-101 e1010294. Doi: 10.21769/BioProtoc.10101294
Chu, S. S., Zhao, Y. Y. and Pan, L. (2018). Intestinal infection in Drosophila larvae and adults. Bio-101 e1010295. Doi: 10.21769/BioProtoc.10101295.
Yu, J. J. and Pan, L. (2019). The Drosophila Hemocytes Ablation Method and Flow Detection Assay. Bio-101 e1010322. Doi: 10.21769/BioProtoc.1010322.
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