占成，教授，博士生导师，免疫应答与免疫治疗全国重点实验室课题组负责人。承担基金委青A、青B、基金委重大项目子课题、国家科技创新2030“脑科学与类脑研究”重大项目子课题等科研项目。近年来以通讯作者身份在Cell, Nature Neuroscience，Neuron，Current Biology, PNAS等国际知名杂志发表多篇论文，累计他引3000余次，h-index 25，最高单篇他引600余次（截至2026年）。现任中国生理学会青年工作委员会和自主神经分会委员，中国神经生物学会应激分会委员。
主要研究兴趣：
大脑是机体的司令部，在调控器官活动和多种生理功能中占据主导地位。我实验室(https://zhanlab.ustc.edu.cn)的研究主要集中在脑—体互作，尤其感兴趣大脑如何调控摄食行为、能量代谢稳态和免疫功能。我们从系统神经生物学整体观出发开展研究，立足本实验室的原创性发现，揭示神经-代谢-免疫的交互机制。此外，我们还与临床开展密切合作，希望将神经调控整体观思想应用于临床疾病的干预与治疗中，例如造血干细胞移植引起的急性移植物抗宿主病(aGVHD)的预防。研究方向主要归纳为如下两点：
1） 神经-免疫-代谢的反馈调节机制；
2） 神经对免疫相关疾病的调控机制与临床应用。
代表性学术论文(#通讯作者)：
1、 Jing Chen#, Wanqi Chen, Yan Zhang, Qianqian Chen, Kaina Zhang, Suowen Xu, Cheng Zhan#. Brainstem Orexigenic Neurons Drive Long-Term Energy Balance via Distributed Hypothalamic Circuits. Current Biology (2026).
2、 Yue Wu, Yiwen Hou, Dongyao Wang, Liang Wang, Kaidi Song, Guangyu Sun, Aijie Huang, Meijuan Tu, Lu Huang, Jialin Zhou, Weiwei Wu, Baolin Tang#, Cheng Zhan#, Xiaoyu Zhu#. Circadian fluctuation of soluble CD26 dictates the impact of the timing of cord blood transplantation on acute graft-versus-host disease. Nature Communications (2026).
3、 Guodong Pang, Yuyan Shi, Jiayi Shen, Tianyu Shao, Fengchao Wang, XYijing Wang#, and Cheng Zhan#. Selectively Labeling and Distinguishing Adrenergic and Noradrenergic Neurons in the Sympathetic Nervous System. Neuroscience Bulletin (2025)
4、 Mingxiu Cheng, Meiqi Wang, Liang Wang, Fangfan Yin, Jiayi Shen, Xin Xing, Yuyan Shi, Zhiwei Liu, Ping Wu, Wenling Gao, Yanyan Fan, Peng Cao, and Cheng Zhan#. Brainstem catecholaminergic neurons induce torpor during fasting by orchestrating cardiovascular and thermoregulation changes. Nature Communications (2025)
5、 Yiwen Hou, Yue Wu, Yang Cao, Xiaoxia Hu, Yuqian Sun Hongmei Wang, Liang Wang, Jialin Zhou, Zhonglin Zhang, Zhiwei Liu, Baolin Tang, Kaidi Song, Guangyu Sun, Wen Gao, Tianqi Zheng, Ping Wu, Weiwei Wu, Dapeng Ju, Xiaoyu Zhu#, Cheng Zhan#. Optimizing Stem Cell Infusion Timing in the Prevention of Acute Graft versus Host Disease. Cell (2025).
6、 Jiayi Shen, Mengtian Wang, Guodong Pang, Yan Zhang, Jian Zhang, Yuyan Shi, Ji Liu#, and Cheng Zhan#. GLP-1 receptor agonist exendin-4 suppresses food intake by inhibiting hindbrain orexigenic NPY neurons. American Journal of Physiology-Endocrinology and Metabolism (2025).
7、 Yan Zhang, Jiayi Shen, Famin Xie, Zhiwei Liu, Fangfang Yin, Mingxiu Cheng, Liang Wang, Meiting Cai, Herbert Herzog, Ping Wu, Zhi Zhang#, Cheng Zhan#, Tiemin Liu#. Feedforward inhibition of stress by brainstem neuropeptide Y neurons. Nature Communications (2024).
8、 Liang Wang, Mingxiu Cheng, Yucheng Wang, Jing Chen, Faming Xie, Li-Hao Huang, Cheng Zhan#. Fasting-activated neurons regulate immune cell homing and suppress autoimmune diseases in mice. Nature Neuroscience (2024). News and Views, Hunger guides immunity to friend versus foe. N. Or-Geva and L. Steinman, Nature Neuroscience (2024).
9、 Jing Cai, Jing Chen, Joshua Ortiz-Guzman, Jessica Huang, Benjamin R Arenkiel, Yuchen Wang, Yan Zhang, Yuyan Shi, Qingchun Tong#, Cheng Zhan#. AgRP neurons are not indispensable for body weight maintenance in adult mice. Cell Reports (2023).
10、 Meiqi Wang, Cheng Zhan#. Anatomical analysis of sensory ganglia in mice. Stress and Brain (2022).
11、 Jing Chen, Chunli Li, Zhonghua Lu, Cheng Zhan#. Optimal Timing of a Commonly-Used Rabies Virus for Neural Recording and Manipulation. Neuroscience Bulletin (2022).
12、 Jing Chen, Minxiu Cheng, Liang Wang, Lei Zhang, Dan Xu, Peng Cao, Fengchao Wang, Herbert Herzog, Sen Song, Cheng Zhan#. A vagal-NTS neural pathway that stimulates feeding. Current Biology (2020).
13、 L. Mei, Y. Fan, M. Wang, X. Lv, C. Zhan#, E. Zhang#. Longitudinal in vivo recording of clock gene transcription in the brains of freely-moving mice. PNAS (2018). Selected for F1000Prime.
14、 Z. Zhao, L. Wang, W. Gao, F. Hu, J. Zhang, Y. Ren, R. Lin, Q. Feng, M. Cheng, D. Ju, Q. Chi, D. Wang, S. Song, M. Luo and C. Zhan#. A Central Catecholaminergic Circuit Controls Blood Glucose Levels during Stress. Neuron (2017). Featured Article.
15、 D. Wang, X. He, Z. Zhao, Q.Feng, R.Lin, Y. Sun, T. Ding, F. Xu #, M. Luo #, C. Zhan #. Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons. Frontiers in Neuroanatomy (2015).
16、 C. Zhan*#, J. Zhou *, Q. Feng, J. Zhang, S. Lin, J. Bao, P. Wu, M. Luo #, Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively. J Neuroscience (2013).
17、 C. Zhan, M. Luo, Diverse patterns of odor representation by neurons in the anterior piriform cortex of awake mice. J Neuroscience (2010).
综述文章
1、 Jing Chen, Meiting Cai, Cheng Zhan#. Neuronal Regulation of Feeding and Energy Metabolism: A Focus on the Hypothalamus and Brainstem. Neuroscience Bulletin (2024).
2、 Jing Chen, Cheng Zhan#. Gut–vagus–NTS neural pathway in controlling feeding behaviors. Stress and Brain (2023).
3、 Zeng, W.#, Yang, F.#, Shen, W.L.#, Zhan, C.#, Zheng, P.#, and Hu, J. Interactions between central nervous system and peripheral metabolic organs. Science China Life Science (2022).
4、 占成，摄食行为的神经调控。中国科学.生命科学 (2020).
5、 Zhan C#. POMC Neurons: Feeding, Energy Metabolism, and Beyond. In Neural Regulation of Metabolism. Springer (2018).
联系方式：
实验室主页：https://zhanlab.ustc.edu.cn/
招生专业：神经生物学，细胞生物学，生物物理
实验室招聘免疫学或者医学背景的博士后和特任副研究员，同时欢迎上述背景的学生来本实验室攻读博士学位。