陈竹，风湿免疫科主任，主任医师，博士生导师，特任研究员，德国埃尔朗根-纽伦堡大学医学博士，美国康奈尔大学纽约特种外科医院博士后，安徽省首届青年江淮名医，安徽省教育厅领军人才特聘教授，安徽省杰出青年基金获得者，安徽省学术与技术带头人后备人选，安徽省委首批平台引进高层次人才，卫生部第32期日中笹川医学奖学金获得者。现任中华医学会风湿病学分会青年委员，安徽省医学会风湿病学分会副主任委员。从事风湿免疫病的临床和科研工作20余年，主要研究方向为类风湿关节炎和系统性红斑狼疮发病机制及靶向治疗，首次报道了年龄相关B细胞在类风湿关节炎中的致病机制，在国际上首次开展了体内原位生成CAR-T治疗系统性红斑狼疮和第4代CAR-T治疗难治性类风湿关节炎的临床研究，代表性成果以第一/通讯作者发表在NEJM, Cell Research, Nature Communications, Nature Reviews Rheumatology, Annals of the Rheumatic Diseases, Arthritis & Rheumatology等国际权威期刊，主持国家自然科学基金3项，安徽省杰出青年基金等省部级基金5项，获得安徽省科技进步二等奖1项和安徽医学科技奖一等奖1项，培养博士研究生4人，博士后2人，硕士研究生10人，担任BMC Medicine编委，Rheumatology and Immunology Research编委，获得国际会议青年研究者奖3次，代表团队在国际会议上作口头学术报告15次（特邀专题报告3次）。
学习及工作经历
1996-2001: 安徽医科大学，医学学士
2004-2007: 安徽医科大学，内科学硕士（风湿病）
2012-2015: 德国埃尔朗根-纽伦堡大学，医学博士（风湿病）
2001-2007: 安徽省立医院，住院医师
2008-2016: 安徽省立医院，主治医师
2009-2010: 日本庆应大学，访问学者
2017-2021: 中国科学技术大学附属第一医院，副主任医师
2018-2020: 康奈尔大学附属纽约特种外科医院，博士后
2022-至今: 中国科学技术大学附属第一医院，主任医师
研究兴趣/方向
1. B细胞在自身免疫病中的发病机制
2. 多组学解析类风湿关节炎滑膜微环境
3. 靶向B细胞治疗复发难治性自身免疫病
联系方式:
E-mail: doczchen@ustc.edu.cn
Phone: +86 551-62284920
代表性论文
1.Wang Q, Xiao ZX, Zheng X, Wang G, Yang L, Shi L, Xiang N, Wang X, Zha GF*, Schett G*, Chen Z*. In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus. New England Journal of Medicine, 2025 Oct 16;393(15):1542-1544.
2.Cai M, Li Z, Wen X, Jin HZ, Li Y, Wu H*, Yang C*, Chen Z*. C3a-C3aR1-mediated interactions between fibroblast-like synoviocytes and macrophages promote the progression of rheumatoid arthritis. Arthritis & Rheumatology, 2025 July 14. Online ahead of print.
3.Li YJ, Li SJ, Zhao X, Sheng J, Xue L, Schett G, Shi C, Hu B*, Wang X*, Chen Z*. Fourth-generation chimeric antigen receptor T-cell therapy is tolerable and efficacious in treatment-resistant rheumatoid arthritis. Cell Research. 2025 Mar;35(3):220-223.
4.Li YJ, Cai M, Qin Y, Dai X, Liang L, Li Z, Wen X, Jin H, Yang C*, Chen Z*. MTHFD2 promotes osteoclastogenesis and bone loss in rheumatoid arthritis by enhancing CKMT1‑mediated oxidative phosphorylation. BMC Medicine. 2025, 23(1):124.
5.Jin HZ, Cai ML, Wang X, Li Z, Ma B, Niu L, Wang P, Pan HF, Li SD, Bao W, Wang GS, Li XM, Xie C*, Chen Z*. Effectiveness and safety of Belimumab and Telitacicept in systemic lupus erythematosus: a real-world, retrospective, observational study. Clinical Rheumatology. 2025 Jan;44(1):247-256.
6.Cai ML, Wu T, Jin HZ, Li Z, Li Y, Chen Z*. Association of serum folate concentrations with cancer mortality among patients with arthritis: a prospective cohort study. BMC Public Health. 2024, 24:3494.
7.Jin HZ, Li YJ, Wang X, Li Z, Ma B, Niu L, Wang P, Pan HF, Li SD, Bao W, Wang G, Li X, Chen Z*. Efficacy and safety of telitacicept in patients with systemic lupus erythematosus: a multicentre, retrospective, real-world study. Lupus Science & Medicine. 2023 Nov 24;10(2):e001074.
8.Cai M, Qin Y, Wan A, Jin H, Tang J, Chen Z* COX5A as a potential biomarker for disease activity and organ damage in lupus. Clinical and Experimental Medicine. 2023 Dec;23(8):4745-4756.
9.Xiang N, Li YJ, Liu MY, Wu QQ, Zhang YX, Jin HZ, Wang Q, Li YW, Tong DL, Xue T, Jin TC, Bao W*, Chen Z*. Antibody responses following the surge of SARS-CoV-2 Omicron infection among patients with systemic autoimmune rheumatic diseases. Rheumatology Advances in Practice. 2023 Jul 24;7(2): rkad064.
10.Li ZY, Cai ML, Qin Y, Chen Z*. Age/autoimmunity-associated B cells in inflammatory arthritis: An emerging therapeutic target. Frontiers in Immunology, 2023,14: 1103307. doi: 10.3389/fimmu.2023.1103307
11.Qin Y, Cai ML, Jin HZ, Huang W, Zhu C, Bozec A, Huang J*, Chen Z*. Age-associated B cells contribute to the pathogenesis of rheumatoid arthritis by inducing activation of fibroblast-like synoviocytes via TNF-α-mediated ERK1/2 and JAK-STAT1 pathways. Annals of the Rheumatic Diseases. 2022 Nov;81(11):1504-1514.
12.Chen Z, Castro DF, Gupta S, Phalke S, Manni M, Rivera-Correa J, Jessberger R, Zaghouani H, Giannopoulou E, Pannellini T, Pernis AB*. IL-13Rα1-Mediated Signaling Regulates Age-Associated/Autoimmune B-Cell Expansion. Arthritis & Rheumatology, 2022 Sep;74(9):1544-1555.
13.Chen Z, Bozec A, Ramming A, Schett G*. Anti-Inflammatory and Immune-Regulatory Cytokines in Arthritis. Nature Reviews Rheumatology. 2019 Jan;15(1):9-17.
14.Chen Z, Andreev D, Oeser K, Krljanac B, Hueber A, Kleyer A, Voehringer D, Schett G*, Bozec A*. Th2 and eosinophil responses suppress inflammatory arthritis. Nature Communications. 2016 Jun 7;7:11596. doi: 10.1038/ncomms11596
15.Qin Y, Jin HZ, Li YJ, Chen Z*. Emerging role of eosinophils in resolution of arthritis. Frontiers in Immunology, 2021, 12:764825. doi: 10.3389/fimmu.2021.764825
16.Li YJ, Chen Z*. Cell-based therapies for rheumatoid arthritis: opportunities and challenges. Therapeutic Advances in Musculoskeletal Disease. 2022 May 23;14:1759720X221100294.
17.Zhang Y, Qin Y, Chen Z*. Neuromedin U suppresses collagen-induced arthritis through ILC2-Th2 activation. Journal of Immunology Research, 2021, 2021:5599439, doi: 10.1155/2021/5599439.
18.Fang W, Zhang Y, Chen Z*. Innate lymphoid cells in inflammatory arthritis. Arthritis Research & Therapy, 2020, 22 (1), 25.