苏枭，博士，中国科学院特聘研究岗位（二级研究员），博士生导师。2004年获复旦大学和美国UCSF联合培养博士学位；2004-2007美国UCSF博士后；2007-2012美国UIC助理研究教授和UCSF副研究员；2012年担任呼吸道感染免疫课题组组长。主持国家自然基金重点项目、重大项目集成重点、重点专项、国家自然基金重大培育和面上项目（多项）；上海市基础重点；承担国家重点研发计划和中国科学院先导B项目等。现任上海市肺部炎症和损伤重点实验室副主任、上海市免疫学感染免疫专业委员会委员、牛津大学出版社QJM杂志（IF14）常务副主编, Mol Med副主编等。在Nature Med、Lancet、JCI、Cell Discovery等杂志发表论文100多篇，引用率6200多次。获得美国Parker B. Francis肺生物医学奖、美国NIH Ruth L. Kirschstein奖、市级科技进步一等奖等。担任国家自然基金杰/优青、重大、重点、国家重点研发计划、香港科学基金评审专家等。参与制订国家自然科学基金呼吸领域十三、十四五战略规划等。
提出“肺副交感神经炎症反射弧”理论，建立了研究迷走神经调控肺部感染免疫的方法体系。发现迷走神经通过α7型烟碱型乙酰胆碱受体调控细菌和病毒感染（包括流感病毒、SARS-CoV-2等），参与肺损伤修复和哮喘的分子机制。还发现感觉神经元识别肺内病原和应答的神经环路，解析迷走神经电刺激和中府穴电针刺激调控肺部免疫的机制等，开拓了神经调控肺部免疫的领域。近期工作如下：
1. 急性肺损伤的发病和修复机制 (Lancet, 2020; Cell Mol Immunol, 2021; Emerg Microbes Infect, 2020; Cell Death Dis, 2020; Stem Cells, 2023)
2. 迷走神经调控急性肺损伤及其修复 (JCI Insight, 2023 cover page; Stem Cell Res & Therapy, 2020a&b; Cell Discov, 2017; Mol Med 2017)
3. 迷走神经调控病毒复制和致病机制 (Mol Therapy, 2024; JMV, 2024; Cell Insight, 2022; J Mol Cell Biol, 2023; Virologica Sinica, 2023; Acta Pharmacol Sin, 2021)
4. 迷走神经调控哮喘的分子机制 (Cell Death Dis, 2023; Front Immunol, 2022; Eur J Immunol, 2020; J Cell Mol Med, 2021; Immunol Cell Biol, 2020 Editor’s top 10)
近期发表论文：
1. Zhao C, Chen J, Liu Z, Liang H, Chen X, Cheng L, Xie S, Lin Z, Wu R, Zhao Q, Xue Y, Lai X, Jin X, Xu J and Su X*. Activation of nicotinic acetylcholine receptor α7 subunit limits ZIKV infection via promoting autophagy and ferroptosis. Molecular Therapy 2024 May 30:S1525-0016(24)00339-3. doi: 10.1016/j.ymthe.2024.05.037.
2. Chen X, Zhang C, Wei T, Chen J, Pan T, Li M, Wang L, Song J, Chen C, Zhang Y, Song Y, Su X*. Activation of α7nAChR in AT2 promotes alveolar regeneration through WNT7B signaling in acute lung injury. JCI Insight2023 Aug 8;8(15):e162547. doi: 10.1172/jci.insight.162547.
3. Chen J, Lai X, Song Y and Su X*. Neuro-immune Recognition and Regulation in the Respiratory System. European Respiratory Review2024; 0: 240008 [DOI: 10.1183/16000617.0008-2024].
4. Du J, Liu Y, Lan G, Zhou Y, Ni Y, Liao K, Zheng F, Cheng Q, Shi G, Su X*. PTRF-IL33-ZBP1 signaling mediating macrophage necroptosis contributes to HDM-induced airway inflammation. Cell Death Dis. 2023 Jul 15;14(7):432. doi: 10.1038/s41419-023-05971-1.
5. Zhao C, Pan M, Chen C, Wei D, Li L, Jiang Y, Zhang Y, Liu W, Zhang X, Matthay MA, Wang H, Jin X, Xu J and Su X*. Cholinergic-α7 nicotinic acetylcholine receptor signaling promotes influenza replication. J Med Virology 2024.
6. Liu L, Zhang DY, Xu JY, Dai HP, Tang N, Su X, Cao B. SARS-CoV-2 viral sepsis: from bedside to bench. Lancet. 2020 May 9;395(10235):1517-1520. doi: 10.1016/S0140-6736(20)30920-X.
7. Huang X, Hao S, Liu J, Huang Y, Liu M, Xiao C, Wang Y, Pei S, Yu T, Xu J, Wang H, Dai D, Su X*, Xiao Y*. The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity. Cell Mol Immunol. 2021 Apr;18(4):969-978. doi: 10.1038/s41423-021-00660-5.
8. Zhao C, Yang X, Su EM, Huang Y, Li L, Matthay MA*, Su X* Signals of vagal circuits engaging with AKT1 in α7 nAChR+CD11b+ cells lessen E. coli and LPS-induced acute inflammatory injury. Cell Discov. 2017 Apr 11;3:17009. doi: 10.1038/celldisc.2017.9. eCollection 2017.
9. Zhao CQ, Chen J, Cheng LP, Xu KF, Yang YY*, and Su X*. Deficiency of HIF-1α enhances influenza A virus replication by promoting autophagy in alveolar type II epithelial cells. Emerg Microbes Infect. 2020 Dec;9(1):691-706. doi: 10.1080/22221751.2020.1742585.
10. Zhang C, Zhao CQ, Chen XY, Tao RJ, Meng GX, Liu X, Shao CZ*, Su X*. Induction of ASC pyroptosis requires gasdermin or caspase-1/11-dependent mediators and IFN-β from pyroptotic macrophages to Stem Cells. Cell Death Dis. 2020 Jun 18;11(6):470. doi: 10.1038/s41419-020-2664-0.
11. Wen J, Sun J, Tang Y, Zhao J, Su X*. Cholinergic α7 nAChR signaling suppresses SARS-CoV-2 infection and inflammation in lung epithelial cells. J Mol Cell Biol. 2023 Jul 25:mjad048. doi: 10.1093/jmcb/mjad048.
12. Song S, Zhao C, Wen J, Chen J, Lin Z, Xie S, Qi H, Wang J, SuX*. Vagal-mAChR4 signaling promotes MuLV/Friend‐induced acute erythroleukemia. Virologica Sinica. 2023, Doi: 10.1016/j.virs.2023.05.005.
13. Di CX, Jiang YS, Li LL, Qiu WN, Shi MM, Zhu YG, Zhang J, Song YL, Su X*, Qu JM*. ASCs activate cGAS-type I IFNs-IL-7 axis via Pseudomonas aeruginosa-derived outer membrane vesicles to resolve pneumonia. Stem Cells. 2023, DOI: 10.1093/stmcls/sxad016.
14. Li N, Chen J, Xie S, Zhang M, Shi T, He Y, Jie Z*, Su X*. Oral antibiotics relieve allergic asthma in post-weaning mice via reducing iNKT cells and function of ADRB2. Front Immunol. 2022 Oct 25;13:1024235. doi: 10.3389/fimmu.2022.1024235. eCollection 2022.
15. Wen J, Zhao C, Chen J, Song S, Lin Z, Xie S, Qi, H Wang J, Su X*. Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription. Cell Insight, 2022 June 2022；1 (3): 100028. doi.org/10.1016/j.cellin.2022.100028.
16. Gao ZW, Li L, Huang YY, Zhao CQ, Xue SJ, Chen J, Yang ZZ, Xu JF*, Su X*. Vagal-α7nAChR signaling is required for lung anti-inflammatory responses and arginase 1 expression during an influenza infection. Acta Pharmacol Sin. 2021 Jan 7. doi: 10.1038/s41401-020-00579-z.