研究领域

TLR、CLR和RLR等天然免疫受体，既可以识别微生物携带的“模式分子”，启动免疫反应、实施宿主防御，也可以识别坏死细胞分泌的“损伤分子”，参与损伤修复、维持机体稳态。感受到病菌入侵或组织损伤后，TLR、CLR、RLR和cGAS/STING等“模式识别受体”通过复杂的信号分子网络，诱导上千种基因表达，参与炎症反应、免疫调节和组织重建等多种生理过程。但是当这些模式识别信号缺陷或失调时，则会导致慢性感染、炎症和肿瘤等疾病。

我们实验室主要研究方向是阐明模式识别受体信号的转导与调节机制，特别是天然免疫信号在DC细胞中介导T细胞亚群分化，调节免疫应答和免疫耐受的分子机制。最近我们通过一系列筛选发现了在TLR、CLR、RLR和cGAS/STING等天然免疫信号通路中分别起正、负调节作用的一些新分子。结合病人资源和动物模型，揭示了这些分子在天然免疫细胞（特别是树突细胞和巨噬细胞）和上皮细胞中调节细胞因子和干扰素表达，影响细胞代谢和细胞死亡的信号转导和表观遗传学机制。接下来我们将重点研究“模式识别受体”如何区分病原体、共生菌和癌变细胞，以启动合适的T细胞免疫反应的分子和细胞学机制，为研发抵御病菌感染、防治炎症和肿瘤的新策略提供理论依据。

教育背景

1994-09--1997-07   中国科学院上海植物生理研究所   分子遗传学博士

1991-09--1994-07   武汉大学生命科学学院   微生物与免疫学硕士

1987-09--1991-07   武汉大学生命科学学院   微生物与免疫学学士

专利与奖励

奖励信息

（1） 中科院优秀博士论文指导教师, 研究所（学校）, 2017

（2） 最佳青年科学家奖, 特等奖, 其他, 2006

出版信息

发表论文

[1] Hu, Yanxiang, Wen, Jing, Zhang, Bei, Xiao, Hui. Precision control of mTORC1 is crucial for the maintenance and IL-13 responsiveness of alveolar macrophages. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2021, 95: http://dx.doi.org/10.1016/j.intimp.2021.107552.

[2] Chen, Xia, Wang, Li, Cao, Limin, Li, Tiantian, Li, Zhihong, Sun, Yumeng, Ding, Jinqiu, Zhou, Chun, Xie, Yadong, Yue, Nan, Nan, Jing, Jia, XinMing, Peng, Chao, Li, Huabin, Yang, Jinbo, Xiao, Hui. Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2 ' 3 '-Cyclic GMP-AMP and Cisplatin under Steady State and Inflammation. JOURNAL OF IMMUNOLOGY[J]. 2021, 206(9): 2061-2074, http://dx.doi.org/10.4049/jimmunol.2000989.

[3] 肖晖. TSC1 Suppresses Macrophage Necroptosis for the Control of Infection by Fungal Pathogen Candida albicans. Immunohorizons.. 2021,

 [4] Zhou, Chun, Chen, Xia, PlanellsCases, Rosa, Chu, Jiachen, Wang, Li, Cao, Limin, Li, Zhihong, LopezCayuqueo, Karen, I, Xie, Yadong, Ye, Shiwei, Wang, Xiang, Ullrich, Florian, Ma, Shixin, Fang, Yiyuan, Zhang, Xiaoming, Qian, Zhikang, Liang, Xiaozheng, Cai, ShiQing, Jiang, Zhengfan, Zhou, Dongming, Leng, Qibin, Xiao, Tsan S, Lan, Ke, Yang, Jinbo, Li, Huabin, Peng, Chao, Qiu, Zhaozhu, Jentsch, Thomas J, Xiao, Hui. Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. IMMUNITY[J]. 2020, 52(5): 767-U305, http://dx.doi.org/10.1016/j.immuni.2020.03.016.

[5] Xie, Yadong, Zhao, Yifan, Shi, Lei, Li, Wei, Chen, Kun, Li, Min, Chen, Xia, Zhang, Haiwei, Li, Tiantian, MatsuzawaIshimoto, Yu, Yao, Xiaomin, Shao, Dianhui, Ke, Zunfu, Li, Jian, Chen, Yan, Zhang, Xiaoming, Cui, Jun, Cui, Shuzhong, Leng, Qibin, Cadwell, Ken, Li, Xiaoxia, Wei, Hong, Zhang, Haibing, Li, Huabin, Xiao, Hui. Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer. JOURNAL OF CLINICAL INVESTIGATION[J]. 2020, 130(4): 2111-2128, https://www.webofscience.com/wos/woscc/full-record/WOS:000530101000051.

[6] Wenjuan Wang, Zihou Deng, Hongyu Wu, Qun Zhao, Tiantian Li, Wencheng Zhu, Xiongjun Wang, Longhai Tang, Chengshu Wang, ShuZhong Cui, Hui Xiao, Jiangye Chen. A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection. NATURE COMMUNICATIONS[J]. 2019, 10(1): https://doaj.org/article/ac084d58804b4e069be3d084f85f3794.