王夏琼，博士，特任副研究员。2016年毕业于中国科学技术大学生命科学学院，获得理学博士学位。2016-2021年，在中国科学技术大学生命科学与医学部及附属第一医院从事博士后研究工作；2021-至今，任中国科学技术大学生命科学与医学部特任副研究员。  

    主要聚焦“危险信号”感应受体的发现、活化和疾病机制研究，相关成果发表在Nat Immunol、Immunity、Cell Mol Immunol等学术期刊。主持国家自然科学面上项目、青年基金和安徽省自然科学基金等研究项目。获国家自然科学二等奖（4/5）、安徽省自然科学一等奖（4/4）、中科院院长特别奖。入选安徽省杰青和中科院青促会会员。

 主要研究兴趣：

1）无菌性炎症中的危险感应受体的鉴定；

2）靶向危险信号感应受体的药物发现

代表论文：

 1. Wang X^#, Cai J^#, Lin B^#, Ma M, Tao Y, Zhou Y, Bai L, Jiang W*, Zhou R*. GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair. Immunity. 2021 Jun 8;54(6): 1123-1136.e8.

2. Wang X^#, Jiang W^#, Yan Y, Gong T, Han J, Tian Z*, Zhou R*. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat Immunol. 2014,15(12):1126-33.

3. Yan J, Zhang C, Xu Y, Huang Z, Ye Q, Qian X, Zhu L, Huang G, Wang X*, Jiang J*, Zhou R*. GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity, Nature Immunology, 2024, 2024(25): 2057-2067

4. Lin B^#, Zhou Y^#, Huang Z^#, Ma M, Qi M, Jiang Z, Li G, Xu Y, Yan J, Wang D, Wang X*, Jiang W*, Zhou R*. GPR34 senses demyelination to promote neuroinflammation and pathologies. Cellular & Molecular Immunology. 2024 Jul 19. doi: 10.1038/s41423-024-01204-3.

5. Zhou Y, Huang Z^#, Lin B^#, Ma M, Hao Y, Liu J, Xu W, Huang G, Mo W, Wang X*, Jiang W*, Zhou R*. Demyelination-derived lysophosphatidylserine promotes microglial dysfunction and neuropathology in a mouse model of Alzheimer’s disease, Cellular Molecular Immunology, 2025, 2025(22): 134-149

6. Zheng X^#, Hou Y^#, He H, Chen Y，Zhou R，Wang X*，Gong T* , Jiang W*. Synthetic vitamin K analogs inhibit inflammation by targeting the NLRP3 inflammasome. Cellular & Molecular Immunology. 2020: 1-9.

7. Yan Y^#, Jiang W^#, Liu L, Wang X, Ding C, Tian Z*, Zhou R*. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell. 2015 Jan 15;160(1-2):62-73.

8. Tang T^#, Lang X^#, Xu C, Wang X, Gong T, Yang Y, Cui J, Bai L, Wang J, Jiang W*& Zhou R*, CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation, Nature Communications. 2017 Aug 4;8(1):202.

9. Huang Y^#, Jiang H^#, Chen Y, Wang X, Yang Y, Tao J, Deng X, Liang G, Zhang H, Jiang W*, Zhou R*. Tranilast directly targets NLRP3 to treat inflammasome-driven diseases. EMBO Mol Med. 2018 Apr;10(4).

10. Zhou X^#, Dong T^#, Fan Z, Peng Y, Zhou R, Wang X, Song N, Han M, Fan B, Jia J, Liu S*. Perfluorodecanoic acid stimulates NLRP3 inflammasome assembly in gastric cells. Sci Rep. 2017 Apr 3;7:45468. doi: 10.1038/srep45468.

11. Gong T^#, Wang X, Yang Y, Zhou R*, Jiang W*, Plant Lectins Activate the NLRP3 Inflammasome To Promote Inflammatory Disorders, The Journal of Immunology. 2017.01.13

12. Jiang W^#, Wang X, Zeng B, Liu L，Tardive A, Wei H, Han J, MacDonald HR, Tschopp J, Tian Z*, Zhou R*, Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes, The Journal of Experimental Medicine. 2013.09.23, 210(11):2465~2476

联系方式：

TEL: +86-551-63600130

E-mail: wxq1989@ustc.edu.cn