主要研究兴趣和方向：

1. 器官间相互作用在心脏疾病中的调控作用

2. 利用多组学数据和系统遗传学探究心血管代谢疾病的遗传机制

3. 肝脏代谢和肠道微生物对心脏疾病的调控

4. 线粒体功能在心血管代谢疾病中的作用

特任研究员，博士生导师。2015年博士毕业于中国科学技术大学,2015年至2023年先后在美国华盛顿大学、耶鲁大学和加州大学洛杉矶分校任博士后和助理研究员。2023年4月加入中国科学技术大学生命科学与医学部。主要研究兴趣为心血管代谢疾病，包括心力衰竭、肥胖、糖尿病、线粒体代谢、肠道菌群等。主要工作发表于Science，Circulation，Circulation Research, Nature Communications, EMBO Journal等期刊上。曾获得博士研究生国家奖学金，优秀论文奖，Young Investigator Award, Popjak Scholar Award等荣誉。

课题组招聘：

课题组招聘对细胞生物学、分子生物学、心血管和代谢等方向感兴趣的博士后、特任副研究员、研究生和科研助理。简历发送至yangcao208@ustc.edu.cn。

  （1）特任副研究员和博士后：具有细胞分子生物学、生物信息学、心血管代谢等相关背景的已博士毕业或即将博士毕业的科研人员。

  （2）博士生或硕士生：诚挚欢迎对本课题组感兴趣的同学加入课题组，攻读学位。

  （3）科研助理：具有分子生物学、细胞生物学、生理学等相关背景的科研人员。

代表论文：

·       Cao Y, Wang Y-C, Zhou Z, Pan C, Jiang L, Zhou Z, Meng Y, Charugundla S, Li T, Allayee H, Seldin MM, and Lusis AJ. Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure. Science.2022;377(6613):1399-1406.  

·       Cao Y, Pan C, Wang Y-C, Zhou Z, Jedian V, Meng Y, Campbell G, Guardino K, Li C, Wang J, and Lusis AJ. Identification of DNA Damage Repair Enzyme Ascc2 as Causal for Heart Failure with Preserved Ejection Fraction (HFpEF). Circulation. 2022 Apr 5;145(14):1102-1104.

·       Cao Y, Vergnes L, Wang Y-C, Pan C, Krishnan KC, Moore TM, Rosa-Garrido M, Kimball TH, Zhou Z, Charugundla S, Rau CD, Seldin MM, Wang J, Vondriska TM, Wang Y, Reue K, and Lusis AJ. Sex Differences in Heart Mitochondria Regulate Diastolic Dysfunction. Nature Communications. 13, 3850 (2022).

·       Cao Y^#, Bojjireddy N^#, Kim M, Li T, Zhai P, Nagarajan N, Sadoshima J, Palmiter RD, Tian R. Activation of γ2-AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury. Circ Res. 2017 Oct 27;121(10):1182-1191.

·       Cao Y^#, Guo WT^#, Tian S, He X, Wang XW, Liu X, Gu KL, Ma X, Huang D, Hu L, Cai Y, Zhang H, Wang Y, Gao P. miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency. EMBO J. 2015 Mar 4;34(5):609-23. doi: 10.15252/embj.201490441. Epub 2015 Jan 20.

·       Cao Y^#, Aquino-Martinez R^#, Hutchison E^#, Allayee H, Lusis AJ*, and Rey FE. Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach. Mol Metab. 2022 Jul 20:101557. doi: 10.1016/j.molmet.2022.101557.

·       Wang YC, Cao Y, Pan C, Zhou ZQ, Yang LL, Lusis AJ. Heterogeneity of small intestinal immune and epithelial cells and their cellular response network to a western diet. Journal of Experimental Medicine. 2023. In press.

·       Li T, Zhang Z, Kolwicz SC Jr, Abell L, Roe ND, Kim M, Zhou B, Cao Y, Ritterhoff J, Gu H, Raftery D, Sun H, Tian R. Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury. Cell Metab. 2017 Feb 7;25(2):374-385. doi: 10.1016/j.cmet.2016.11.005.

·       Moore T, Cheng L, Wolf D, Ngo J, Segawa M, Zhu X, Strumwasser A, Cao Y, Clifford B, Ma A, Scumpia P, Shirihai O, Vallim T, Laakso M, Lusis AJ, Hevener A, Zhenqi Zhou. Parkin Regulates Adiposity by Coordinating Mitophagy with Mitochondrial Biogenesis in White Adipocytes. Nat Commun. 2022;13(1):6661. Published 2022 Nov 4.

·       Lee CF, Cao Y, Tian R. Failed Power Plant Turns into Mass Murder: New Insight on Mitochondrial Cardiomyopathy. Circ Res. 2018 Jan 5;122(1):11-13. doi: 10.1161/CIRCRESAHA.117.312288.

·       Gao P^*, Sun L, He X, Cao Y, Zhang H. MicroRNAs and the Warburg Effect: new players in an old arena. Curr Gene Ther. 2012 Aug;12(4):285-91. doi: 10.2174/156652312802083620.

联系方式：

办公室：生物楼主楼726

邮箱：yangcao208@ustc.edu.cn