李丰银，教授，博士生导师

2020年3月加入中国科学技术大学生命科学学院，组建实验室。目前为中国科学技术大学生命科学学院和附属第一医院双聘青年杰出人才。2013年7月博士毕业于中国农业大学生化分子生物学专业；2013年8月至2018年9月赴美国爱荷华大学微生物与免疫学系从事博士后研究；2018年9月至2019年10月，以Assistant Research Scientist身份在该系开展研究工作。在Nat Immunol（四篇）、Cell Stem Cell（封面文章）、Nat Commun（两篇）、J Exp Med、Cell Reports、J Biol Chem、J Immunol和FASEB J等国际高水平杂志发表研究性学术论文13篇。其中，两篇论文被Faculty 1000收录并推荐为“Very good”，并被HematologyTimes、CBS News、The Daily Iowan等媒体积极报道。获2012年首届博士生国家奖学金和2017年Dorfman Research Award奖。

主要研究兴趣：

1. 参与抗病毒感染与炎症中T淋巴细胞的转录与表观遗传调控机制

2. 常见自身免疫性疾病的发病机理以及药物研发的生物学基础

3. 髓系和淋巴系胸腺T淋巴细胞早期谱系分化的机制研究及与白血病等重大疾病的关系

近期发表文章:

1. Fengyin Li, Bing He, Xiaoke Ma, Shuyang Yu, Rupali R. Bhave, Steven R. Lentz, Kai Tan, Monica L. Guzman, Chen Zhao, Hai-Hui Xue. (2017). Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1. Cell Stem Cell (Cover story) 21, 1-15.

2. Shaojun Xing^#, Fengyin Li^#, Zhouhao Zeng#, Yunjie Zhao, Shuyang Yu, Qiang Shan, Yalan Li, Farrah C Phillips, Peterson K Maina, Hank H Qi, Chengyu Liu, Jun Zhu, R Marshall Pope, Catherine A Musselman, Chen Zeng, Weiqun Peng^*, Hai-Hui Xue^*. (2016). Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity. Nat Immunol 17, 695-703. (Co-first author)

3. Fengyin Li, Zhouhao Zeng, Shaojun Xing, Jodi A. Gullicksrud, Qiang Shan, Jinyong Choi, Vladimir P. Badovinac, Shane Crotty, Weiqun Peng & Hai-Hui Xue^*. (2018). Ezh2 programs T_FH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf. Nat Commun 9, 1-18.

4. Cong Lv^#, Fengyin Li^#, Xiang Li^#, Yuhua Tian^#, Yue Zhang, Xiaole Sheng, Yongli Song, Qingyong Meng, Shukai Yuan, Liming Luan, Thomas Andl, XuFeng, Baowei Jiao, Mingang Xu, Maksim V. Plikus, Xing Dai, ChristopherLengner, Wei Cui, Fazheng Ren, Jianwei Shuai, Sarah E. Millar, Zhengquan Yu^*. (2017). MiR-31 promotes mammary stem cell expansion and breast tumorigenesisby suppressing Wnt signaling antagonists. Nat Commun 8, 1-18. (Co-first author)

5. Shuyang Yu^#, Fengyin Li^#, Shaojun Xing, Tianyan Zhao, Weiqun Peng, Hai-Hui Xue^*. (2016). Hematopoietic and Leukemic Stem Cells Have Distinct Dependence onTcf1 and Lef1 Transcription Factors. J Biol Chem 291, 11148-11160. (Co-first author)

6. Yue Zhang^#, Fengyin Li^#, Yongli Song, Xiaole Sheng, Kai Xiong, Lei Chen, Dequan Liu, Christopher Lengner, Lixiang Xue, Zhengquan Yu^*. (2016). Numb and Numbl act to determine mammary myoepithelial cell fate,maintain epithelial identity, and support lactogenesis. FASEB J 30, 3474-3488. (Co-first author)

7. Peng Shao^#, Fengyin Li^#, Jinyong Wang, Xia Chen, Chenyu Liu and Hai-Hui Xue^* (2019). Cutting edge: Tcf1 instructs follicular helper cell differentiation by repressing blimp1 in response to acute viral infection. J Immunol, 203: 801-806 (Co-first author)

8. Qiang Shan^#, Zhouhao Zeng^#, Shaojun Xing, Fengyin Li, Stacey M Hartwig, Jodi A Gullicksrud, Samarchith P Kurup, Natalija Van Braeckel-Budimir, Yao Su, Matthew D Martin, Steven M Varga, Ichiro Taniuchi, John T Harty, Weiqun Peng, Vladimir P Badovinac^*, Hai-Hui Xue^*. (2017). The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage. Nat Immunol 18, 931-939.

9. Jodi A. Gullicksrud, Fengyin Li, Shaojun Xing, Zhouhao Zeng, Weiqun Peng, Vladimir P. Badovinac, John T. Harty, Hai-Hui Xue^*. (2017). Differential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection. J Immunol 3, 911-919.

10. Yan Xiu, Qianze Dong, Qingchang Li, Fengyin Li, Nick Borcherding, Weizhou Zhang, Brendan Boyce, Hai-hui Xue^*, Chen Zhao^*. (2018). Stabilization of NF-KB-inducing kinase suppresses MLL-AF9–induced acute myeloid leukemia. Cell reports 2, 350-358.

11. Shaojun Xing, Peng Shao, Fengyin Li, Xudong Zhao, WooseokSeo, Justin C. Wheat, Selvi Ramasamy, Jianfeng Wang, Xiang Li, Weiqun Peng, Shuyang Yu, Chengyu Liu, Ichiro Taniuchi, David A. Sweetser, Hai-Hui Xue^*. (2018). Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity. J Exp Med 8, 2211-2226.

12. Qi Yang, Fengyin Li, Christelle Harly, Shaojun Xing, Longyun Ye, Xuefeng Xia, Haikun Wang, Xinxin Wang, Shuyang Yu, Xinyuan Zhou, Maggie Cam, Hai-Hui Xue^*, Avinash Bhandoola^*. (2015). TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nat Immunol 16, 1044-1050.

13. Youn Soo Choi^#, Jodi A Gullicksrud^#, Shaojun Xing, Zhouhao Zeng, Qiang Shan, Fengyin Li, Paul E Love, Weiqun Peng, Hai-Hui Xue^*, Shane Crotty^*.(2015).LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6. Nat Immunol 16, 980-990.

团队招聘：

特任副研究员及博士后，需具有免疫学、生化分子生物学或者细胞生物学背景（有生物信息学分析、病毒感染或者免疫性疾病动物模型实验经验者优先考虑），近期取得博士学位，可独立开展相关科研工作及指导学生，有很好的Motivation、强烈的Enthusiasm和Responsibility；同时热诚欢迎对实验室研究方向感兴趣的本科生前来攻读博士学位。另外，实验室也非常欢迎有兴趣的本科生提早进入实验室开展科研训练。

长期招聘，欢迎邮件联系！

联系方式：

电话：17352982186

邮箱：fyli88@ustc.edu.cn