王毅，中国科学技术大学生命科学与医学部，研究员，博士生导师，中国科学院人才计划入选者。2014年毕业于香港大学李嘉诚医学院，博士联合培养就读于美国康奈尔大学化学与化学生物学系，师从霍华德休斯医学研究员（HHMI）Hening Lin教授。2014年起任香港大学李嘉诚医学院博士后、研究助理教授和高级助理研究员。2020年起，中国科学技术大学微尺度物质科学国家研究中心分子医学部/中科院天然免疫与慢性病重点实验室独立PI，组建表观遗传免疫学实验室。近年来研究成果发表在J. Am. Chem. Soc（通讯作者）、Nature、PNAS、Cell Chemical Biology、elife等。

研究兴趣和方向：综合运用化学生物学、细胞生物学和结构生物学的Bio-X 多学科交叉的研究手段，以一系列化学分子探针为基础，在分子、细胞、和病理水平上对蛋白质翻译后修饰调节因子Eraser，Reader，Writer家族在免疫学层面进行深入的机理研究，并设计和筛选出具有高选择性的inhibitor抑制剂和activator激活剂药物用于临床研究。

文章发表

1. 通讯作者

1. Jing Jin, Bin He, Xiaoyu Zhang, Hening Lin, * Yi Wang*. SIRT2 reverses 4-oxononanoyl lysine modification on histones. J. Am. Chem. Soc.,2016, 138 (38), pp 12304–12307.  (*Corresponding author)

2. 第一 /共同第一作者

1. Yi Wang*, Jing Jin*, Matthew Wai Heng Chung*, Ling Feng, Hongyan Sun, Quan Hao. Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation. Proc Natl Acad Sci U S A.2018, Feb 20. pii: 201717664.(* co-first author)

2. Hong Jiang*, Saba Khan*, Yi Wang*, Guillaume Charron, Bin He, Carlos Sebastian, Jin tang Du, Ray Kim, Eva Ge, Raul Mostoslavsky, Howard C. Hang, Quan Hao & Hening Lin. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature.2013, 496, (110–113). (* co-first author)

3. Yi Wang, Yi Man Eva Fung, Weizhe Zhang, Bin He, Matthew Wai Heng Chung, Jing Jin, Jing Hu, Hening Lin, Quan Hao. De-acylation Mechanism by SIRT2 Revealed in the 1’-SH-2’-O-MyristoylIntermediate Structure.Cell Chemical Biology, 2017. 16; 24(3): 339-345.

4. Yi Wang, Sujit Dutta, Helen Karlberg, Stéphanie Devignot, Friedemann Weber, Quan Hao, Yee Joo Tan, Ali Mirazimi and Masayo Kotaka. Structure of Crimean-Congo Hemorrhagic Fever Virus Nucleoprotein: Superhelical Homo-Oligomers and the Role of Caspase-3 Cleavage. J. Virol.2012, 86(22).

5. Xiucong Bao*, Yi Wang*, Xin Li*, Xiao-Meng Li*, Zheng Liu, Tangpo Yang, Chi Fat Wong, Jiangwen Zhang, Quan Hao, Xiang David Li. Identification of ‘erasers, SIRT3’ for lysine crotonylated histone marks using a chemical proteomics approach. Elife.2014; 3: e02999. (* co-first author)

    

3. 其他

1. Ghosh S, Wong SK, Jiang Z, Liu B, Wang Y, Hao Q, Gorbunova V, Liu X, Zhou Z. Haploinsufficiency of Trp53 dramatically extends the lifespan of SIRT6-deficient mice. Elife. 2018, Feb 23;7. pii: e32127.

2. Zhen Tong, Miao Wang, Yi Wang, David D. Kim, Jennifer K. Grenier, Ji Cao, Sushabhan Sadhukhan, Quan Hao, and Hening Lin. SIRT7 is an RNA-activated protein lysine deacylase. ACS Chem. Biol. 2016, DOI: 10.1021/acschembio.6b00954.

3. Yusheng Xie, Jingyan Ge, Haipeng Lei, Bo Peng, Huatang Zhang, Danyang Wang, Sijun Pan, Ganchao Chen, Lanfang Chen, Yi Wang, Quan Hao, Shao Q. Yao, Hongyan Sun. Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases J. Am. Chem. Soc., 2016, 138 (48), pp 15596–15604

4. Shrestha Ghosh, Baohua Liu, Yi Wang, Quan Hao, Zhongjun Zhou. Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair. Cell report. 2015, 1396–1406

5. Zhen Tong, Yi Wang, Xiaoyu Zhang, David D. Kim, Sushabhan Sadhukhan, Quan Hao, and Hening Lin. SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context. ACS Chem. Biol. 2016, 11, 742−747

实验室长期招聘博士后和科研助理，有意者请将个人简历（包括个人基本信息、教育和工作经历、论文发表及其他成果）发至邮箱：wy83@ustc.edu.cn