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刘丹:男,汉族,34岁,于1997年至2007年间就读于中国科学技术大学并获得细胞生物学博士学位,后赴美国宾夕法尼亚大学继续进行博士后研究工作。在求学及从事研究工作期间,一直专注于有丝分裂的激酶调控机制这一方向,在《Science》,《Journal of Cell Biology》,《Molecular Cell》等世界顶级及领域内著名杂志上发表多篇研究论文,研究成果得到同行专家的广泛认可。其中,2009年发表在《Science》上的科研成果已经于2012年被美国经典分子细胞生物学教科书《Molecular Cell Biology》第七版收录。于2013年归国后,加入中国科学技术大学担任教授,博士生导师。

 

主要研究兴趣:

1.有丝分裂激酶去磷酸化酶调控网络的研究。

2.基于有丝分裂激酶去磷酸化酶及其相关底物作用网络的抗癌药物开发。

 

发表文章:

研究论文:

Liu D., Davydenko O., Lampson M.A. Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing. J Cell Biol. 2012 Aug; 198:491-499.

Welburn J.P., Vleugel M., Liu D., Yates III J.R., Lampson M.A., Fukagawa T., Cheeseman I.M. Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface. Mol. Cell. 2010 May; 38:383-392.

Liu D., Vleugel M., Backer C.B., Hori T., Fukagawa T., Cheeseman I.M., Lampson M.A. Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. J Cell Biol. 2010 March; 188:809-820.

Liu D., Vader G., Vromans M.J., Lampson M.A., Lens S.M. Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science. 2009 Mar; 323:1350-1353.

Liu D., Ding X., Du J., Cai X., Huang Y., Ward T., Shaw A., Yang Y., Hu R., Jin C., Yao X. Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment. J Biol Chem. 2007 July; 282:21415-21424.

Liu D.†, Ge L.†, Wang F., Takahashi H., Wang D., Guo Z., Yoshimura S.H., Ward T., Ding X., Takeyasu K., Yao X. Single-molecule detection of phosphorylation-induced plasticity changes during ezrin activation.  FEBS Lett. 2007 Jul; 581:3563-3571. († equal contribution)

Liu D., Zhang N., Du J., Cai X., Zhu M., Jin C., Dou Z., Feng C., Yang Y., Liu L., Takeyasu K., Xie W., Yao X. 2006. Interaction of Skp1 with CENP-E at the midbody is essential for cytokinesis. Biochem Biophys Res Commun. 2006 Apr; 345:394-402.

Xue Y.†, Liu D.†, Fu C., Dou Z., Zhou Q., Yao X. A novel genome-wide full-length kinesin prediction analysis reveals additional mammalian kinesins. Chinese Science Bulletin. 2006 Aug; 51:1836-1847. († equal contribution)

 

综述:

Liu D., Lampson M.A. Regulation of kinetochore-microtubule attachments by Aurora B kinase. Biochem Soc Trans. 2009 Oct; 37(5):976-980.

Liu D., Jin C., Yao X. Progress and perspective of the kinetochore-associated motor proteins. Chinese Science Bulletin. 2003 Jan; 48(2):111-117.

 

联系方式:

电话:0551-63601619

电子邮件: dliu919@ustc.edu.cn