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白  丽

教授,博士生导师

电话:0551-63607897

Email:baili@ustc.edu.cn

实验室主页:http://home.ustc.edu.cn/~zorro220/Baili_Lab

研究兴趣:1) NKT细胞的功能;2)免疫突触的形成及信号传导机制;3)肥胖与组织慢性炎症。

   中国科学院“百人计划”(2011)获得者。2001年毕业于华中科技大学生物系,获理学学士学位;2006年毕业于华中科技大学生物物理专业,获理学博士学位;2006至2010年在霍华德休斯医学研究所,芝加哥大学从事博士后研究。主要研究成果分别发表在Cell Metab,PNAS,J Immunol等期刊上,获Faculty of 1000好评和推荐。现承担国家重大研究计划及国家自然科学基金委等研究课题。 

主要代表性论文:(* 通讯作者)

1. Chen J, Wei Y, He J, Cui G, Zhu Y, Lu C, Ding Y, Xue R, Bai L, Uede T, Li L, Diao H. Natural killer T cells play a necessary role in modulating of immune-mediated liver injury by gut microbiota. Sci Rep. 2014;4:7259.

2. Deng S, Bai L, Reboulet R, Matthew R, Engler DA, Teyton L, Bendelac A, Savage PB. A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses in vivo. Chem Sci. 2014;5(4):1437-1441.

3. Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ.Crystal structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells.Immunity. 2013;39(6):1032-42.

4. Bai L*, Deng SL* , Reboulet R*,  Mathew R , Teyton L, Savage PB , Bendelac A. Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides. Proc Natl Acad Sci USA. 2013;110(40):16097-102.

5. Bai L*, Picard D*, Anderson B, Chaudhary V, Luoma A, Jabri B, Adams EJ, Savage PB, Bendelac A. The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vδ1 TCR. Eur J Immunol. 2012 ; 2(9):2505-10.

6. Bai L* Constantinides MG, Thomas SY, Reboulet R, Meng F, Koentgen F, Teyton L, Savage PB, Bendelac A* Distinct APCs explain the cytokine bias of α-galactosylceramide variants in vivo. J Immunol. 2012;188(7):3053-61.

7. Deng S, Mattner J, Zang Z, Bai L, Teyton L, Bendelac A, Savage PB. Impact of sugar stereochemistry on natural killer T cell stimulation by bacterial glycolipids. Org Biomol Chem. 2011;(22):7659-62.

8. Scanlon ST, Thomas SY, Ferreira CM, Bai L, Krausz T, Savage PB, Bendelac A. Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation. J Exp Med. 2011;208(10):2113-24

9. Bai L, Sagiv Y, Liu Y, Freigang S, Yu KO, Teyton L, Porcelli SA, Savage PB, Bendelac A. Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen aGC. Proc Natl Acad Sci USA. 2009 ;106(25):10254-9.