肖卫华

教授，博士生导师

电话：0551-63606294

Email：xiaow@ustc.edu.cn

实验室主页：http://lstt.ustc.edu.cn

研究兴趣：1)肿瘤及免疫细胞信号网络研究；2)生物技术药物开发；3)主要疾病 (恶性肿瘤、传染病和自身免疫疾病) 。
　　国家杰出青年科学基金B类国内负责人、国家教育部和国家基金委“天然免疫”创新研究群体学术骨干。美国霍普金斯大学生物信息学硕士，吉林大学医学博士。1995年-1998年美国马里兰大学肿瘤研究中心博士后；1998-2004美国国立卫生研究院癌症研究所研究院；2004年-现在，中国科学技术大学教授。现任中国免疫学会抗癌协会副理事长；安徽省生物工程学会副理事长。

　　 已发表SCI论文60余篇，其中以第一或通讯作者在PNAS，Cancer Research, Molecular Cancer Cell, JBC, J Immunol等杂志发表论文30余篇。获国家专利授权10余项。

主要代表性论文：（*通讯作者）

1. Yangyang Li, Siqi Xie, Minhua Chen, Hao Li, Yehai Wang, Yan Fan, Kang An, Yu Wu and Weihua Xiao. Development of an antibody-ligand fusion protein scFvCD16A-sc4-1BBL in Komagataella phaffii with stimulatory activity for Natural Killer cells. Microb Cell Fact. 22, 67 (2023).

2. Fang F, Xie S, Chen M, Li Y, Yue J, Ma J, Shu X, He Y, Xiao W, Tian Z. Advances in NK cell production. Cell Mol Immunol. 2022 Apr;19(4):460-481.

3. Chen, M.; Li, Y.; Wu, Y.; Xie, S.; Ma, J.; Yue, J.; Lv, R.; Tian, Z.; Fang, F.; Xiao, W. Anti-Tumor Activity of Expanded PBMC-Derived NK Cells by Feeder-Free Protocol in Ovarian Cancer. Cancers. 2021, 13, 5866.

4. Huan Xu, Mingyang Shi, Changsheng Shao, Hao Li, Jing Wu, Yin Yu, Fang Fang, Yugang Guo, Weihua Xiao. Development of IL-15/IL-15Rα sushi domain-IgG4 Fc complexes in Pichia pastoris with potent activities and prolonged half-lives. Microb Cell Fact. 20, 115 (2021).

5. Miao Y, Jiang M, Qi L, Yang, Xiao W, Fang F. BCAP Regulates Dendritic Cell Maturation Through the Dual-Regulation of NF-κB and PI3K/AKT Signaling During Infection. Front Immunol. 2020 Feb 18;11:250.

6. Huimin Liu, Siqi Xie, Fang Fang, Dhananjaya V. Kalvakolanu and Weihua Xiao. SHQ1 is an ER stress response gene that facilitates chemotherapeutics-induced apoptosis via sensitizing ER-stress response. Cell Death Dis. 11, 445 (2020).

7. Lu Qi , Qiuyan Zhang, Yuhui Miao, Wenyao Kang, Zhigang Tian, Damo Xu, Weihua Xiao, Fang Fang. Interleukin-33 Activates and Recruits Natural Killer Cells to Inhibit Pulmonary Metastatic Cancer Development. Int J Cancer. 2019 Mar 1;146(5):1421-1434

8. Jia, H., Y. Guo, X. Song, C. Shao, J. Wu, J. Ma, M. Shi, Y. Miao, R. Li, D. Wang, Z. Tian, and W. Xiao. 2016. Elimination of N-glycosylation by site mutation further prolongs the half-life of IFN-alpha/Fc fusion proteins expressed in Pichia pastoris. Microb Cell Fact 15: 209.

9. Wang, D., J. Y. Chen, R. Li, G. L. Wu, Z. M. Sun, Z. T. Wang, Z. M. Zhai, F. Fang, Y. G. Guo, Y. J. Zhong, M. Jiang, H. Xu, M. H. Chen, G. D. Shen, J. Sun, B. L. Yan, C. D. Yu, Z. G. Tian, and W. H. Xiao. 2016. PAX5 interacts with RIP2 to promote NF-kappa B activation and drug-resistance in B-lymphoproliferative disorders. J. Cell Sci. 129: 2261-2272.

10. Guo, Y. G., J. Wu, H. Jia, W. Chen, C. S. Shao, L. Zhao, J. J. Ma, R. Li, Y. J. Zhong, F. Fang, D. Wang, J. Sun, F. Qian, X. R. Dai, G. H. Zhang, Z. G. Tian, B. X. Li, and W. H. Xiao. 2015. Balancing the Expression and Production of a Heterodimeric Protein: Recombinant Agkisacutacin as a Novel Antithrombotic Drug Candidate. Sci Rep 5: 10.

11. Zhong, Y. J., L. Yang, Y. G. Guo, F. Fang, D. Wang, R. Li, M. Jiang, W. Y. Kang, J. J. Ma, J. Sun, and W. H. Xiao. 2014. High-temperature cultivation of recombinant Pichia pastoris increases endoplasmic reticulum stress and decreases production of human interleukin-10. Microb. Cell. Fact. 13: 10.

12. Ren, Z. J., W. Y. Kang, L. H. Wang, B. L. Sun, J. J. Ma, C. G. Zheng, J. Sun, Z. G. Tian, X. Y. Yang, and W. H. Xiao. 2014. E2F1 renders prostate cancer cell resistant to ICAM-1 mediated antitumor immunity by NF-kB modulation. Mol. Cancer 13: 13.

13. Guo, Y. G., R. Li, X. P. Song, Y. J. Zhong, C. G. Wang, H. Jia, L. D. Wu, D. Wang, F. Fang, J. Ma, W. Y. Kang, J. Sun, Z. G. Tian, and W. H. Xiao. 2014. The Expression and Characterization of Functionally Active Soluble CD83 by Pichia pastoris Using High-Density Fermentation. PLoS One 9: 8.

14. Sun, H. Y., C. Sun, and W. H. Xiao. 2014. Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations. Cytokine 65: 33-41.

15. Cheng, M., Y. Y. Chen, W. H. Xiao, R. Sun, and Z. G. Tian. 2013. NK cell-based immunotherapy for malignant diseases. Cell. Mol. Immunol. 10: 230-252.

16. Sun, H. Y., C. Sun, Z. G. Tian, and W. H. Xiao. 2013. NK cells in immunotolerant organs. Cell. Mol. Immunol. 10: 202-212.

17. Ma, Y., Q. Q. Cheng, Z. J. Ren, L. Xu, Y. Zhao, J. Sun, S. Y. Hu, and W. H. Xiao. 2012. Induction of IGF-1R expression by EGR-1 facilitates the growth of prostate cancer cells. Cancer Lett. 317: 150-156.

18. Fang, F., Y. Wang, R. Li, Y. Zhao, Y. Guo, M. Jiang, J. Sun, Y. Ma, Z. J. Ren, Z. G. Tian, F. Wei, D. Yang, and W. H. Xiao. 2010. Transcription Factor E2F1 Suppresses Dendritic Cell Maturation. J. Immunol. 184: 6084-6091.

19. Ma, J. J., Z. J. Ren, Y. Ma, L. Xu, Y. Zhao, C. G. Zheng, Y. H. Fang, T. Xue, B. L. Sun, and W. H. Xiao. 2009. Targeted Knockdown of EGR-1 Inhibits IL-8 Production and IL-8-mediated Invasion of Prostate Cancer Cells through Suppressing EGR-1/NF-kappa B Synergy. J. Biol. Chem. 284: 34600-34606.

20. Zheng, C. G., Z. J. Ren, H. T. Wang, W. C. Zhang, D. V. Kalvakolanu, Z. G. Tian, and W. H. Xiao. 2009. E2F1 Induces Tumor Cell Survival via Nuclear Factor-kappa B-Dependent Induction of EGR1 Transcription in Prostate Cancer Cells. Cancer Res. 69: 2324-2331.

21. Xiao, W. H., D. R. Hodge, L. H. Wang, X. Y. Yang, X. H. Zhang, and W. L. Farrar. 2004. NF-kappa B activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NF kappa B regulatory site in autocrine human multiple myeloma cells. Cancer Biol. Ther. 3: 1007-1017.

22. Xiao, W. H., L. H. Wang, X. Y. Yang, T. S. Chen, D. Hodge, P. F. Johnson, and W. Farrar. 2001. CCAAT/enhancer-binding protein beta mediates interferon-gamma-induced p48 (ISGF3-gamma) gene transcription in human monocytic cells. J. Biol. Chem. 276: 23275-23281.

23. Xiao, W. H., S. Ramanujam, D. J. Lindner, R. D. Kudaravalli, R. Freund, and D. V. Kalvakolanu. 1998. The polyoma virus T antigen interferes with interferon-inducible gene expression. Proc. Natl. Acad. Sci. U. S. A. 95: 1085-1090.

24. Xiao, W. H., V. Kolla, and D. V. Kalvakolanu. 1997. Interferon gamma-induced transcription of the murine ISGF3 gamma (p48) gene is mediated by novel factors. Proc. Natl. Acad. Sci. U. S. A. 94: 103-108.

25. Xiao, W. H., D. J. Lindner, and D. V. Kalvakolanu. 1997. The interferon-inducible murine p48 (ISGF3 gamma) gene is regulated by protooncogene c-myc. Proc. Natl. Acad. Sci. U. S. A. 94: 7227-7232.