郑晓东
副教授
电话:63600845
Email:zhxdd@ustc.edu.cn
2007年获中国科技大学博士学位,2007-2009年中国科技大学博士后,在JBC、JI等国际期刊上发表论文十余篇,主要从事NK细胞杀伤靶细胞的分子识别机制和基因工程药物重组人IL-12等方面的研究。先后承担了国家973项目,自然科学基金(青年基金)项目、中国博士后科学基金特别资助项目等项目,获国家自然科学二等奖1项,中华医学会一等奖1项,安徽省自然科学一等奖1项
主要代表性论文:
1.Zheng X, Wang Y, Wei H, Ling B, Sun R, Tian Z. Bcl-xL is associated with the anti-apoptotic effect of IL-15 on the survival of CD56(dim) natural killer cells. Mol Immunol. 2008;45(9):2559-69.
2.Zheng X, Wang Y, Wei H, Sun R, Tian Z. LFA-1 and CD2 synergize for the ERK1/2 activation in the NK cell immunological synapse. J Biol Chem. 2009;284(32):21280-7.
3. Bi J, Zheng X, Chen Y, Wei H, Sun R*, Tian Z*. TIGIT safeguards liver regeneration through regulating NK cell-hepatocyte crosstalk. Hepatology. 2014;60(4):1389-98.
4. Hou S, Zheng X, Wei H, Tian Z, Sun R*. Recombinant soluble CD226 protein directly inhibits cancer cell proliferation in vitro. Int Immunopharmacol. 2014;19(1):119-26.
5. Huang H, Zheng X, Tian Z, Sun R. Peptide mimicry of AICL inhibits cytolysis of NK cells by blocking NKp80-AICL recognition. Immunol Invest. 2010;39(6):587-97.
6. Wang H, Zheng X, Wei H, Tian Z, Sun R.Preparation and functional identification of a monoclonal antibody against the recombinant soluble human NKp30 receptor. Int Immunopharmacol. 2011; 11(11):1732-1739.
7. Wang H, Zheng X, Wei H, Tian Z, Sun R. Important role for NKp30 in synapse formation and activation of NK cells. Immunol Invest. 2012;41(4):367-81.
地址:安徽省合肥市黄山路443号中国科学技术大学邮编:230027